Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats.
Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats.
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DOI：
10.1111/j.1460-9568.2011.07649.x
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Mizumori SJ
中科院分区：
文献类型：
--
作者：
Norton AB;Jo YS;Clark EW;Taylor CA;Mizumori SJ
腹侧被盖区（VTA）和黑质（SN）多巴胺（DA）神经元的时相放电可能对指导学习的奖励处理至关重要。参与调节这种DA爆发放电的关键结构之一是脚桥被盖核（PPTg），其投射到VTA和SN。不同的文献认为，PPTg作为DA细胞的感觉门控区或调节随意运动。本研究记录了大鼠执行空间导航任务时的PPTg单单位活动，以检查奖励和运动贡献的潜力。PPTg细胞表现出显着的变化，相对于奖励收购，在迷宫中的运动速度，和大鼠的转向行为。奖励，而不是运动，相关性受到上下文变化的影响，并且两种相关类型都不受奖励操纵（例如改变奖励的预期位置）的影响。这表明PPTg联合编码奖励和行为信息，并且奖励信息以上下文相关的方式处理。奖赏细胞和运动细胞的不同解剖分布强调了腹侧被盖区和黑质区DA爆发性放电的PPTg突触控制的不同模型。然而，与VTA和SN学习系统相关的是，PPTg似乎是一种促进强化学习的感觉门控机制，同时为持续的目标导向行为提供了基于认知的指导。
Phasic firing of dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra (SN) is likely crucial for reward processing that guides learning. One of the key structures implicated in the regulation of this DA burst firing is the pedunculopontine tegmental nucleus (PPTg) which projects to both VTA and SN. Different literatures suggest that PPTg serves as a sensory-gating area for DA cells or it regulates voluntary movement. This study recorded PPTg single unit activity as rats perform a spatial navigation task to examine the potential for both reward and movement contributions. PPTg cells showed significant changes in firing relative to reward acquisition, the velocity of movement across the maze, and turning behaviors of the rats. Reward, but not movement, correlates were impacted by changes in context, and neither correlate type was affected by reward manipulations (e.g. changing the expected location of a reward). This suggests that the PPTg conjunctively codes both reward and behavioral information, and that the reward information is processed in a context-dependent manner. The distinct anatomical distribution of reward and movement cells emphasizes different models of synaptic control by PPTg of DA burst firing in VTA and SN. Relevant to both VTA and SN learning systems, however, PPTg appears to serve as a sensory gating mechanism to facilitate reinforcement learning, while at the same time provides reinforcement-based guidance of ongoing goal-directed behaviors.
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影响因子：
3.3
作者：
MORIIZUMI, T;HATTORI, T
通讯作者：
HATTORI, T
影响因子：
3.8
作者：
GARCIARILL, E;HOUSER, CR;WOODWARD, DJ
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WOODWARD, DJ
影响因子：
3.3
作者：
Keating, GL;Winn, P
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影响因子：
2
作者：
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2.7
作者：
Mizumori, SJY;Yeshenko, O;Davis, DM
通讯作者：
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