Clinical factors to predict flare-up in patients with inflammatory bowel disease during international air travel: A prospective study.
Clinical factors to predict flare-up in patients with inflammatory bowel disease during international air travel: A prospective study.
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DOI：
10.1371/journal.pone.0262571
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Lee DH
中科院分区：
文献类型：
--
作者：
Park J;Yoon H;Shin CM;Park YS;Kim N;Lee DH
炎症性肠病（IBD）患者经常在国际航空旅行期间经历疾病发作。我们的目的是确定国际航空旅行期间与IBD爆发相关的风险因素。从首尔国立大学盆唐医院IBD门诊招募定期国际航空旅行的患者入组研究。通过问卷调查和个人访谈收集飞行信息和临床数据，并确定与IBD发作相关的风险因素。2018年5月至2020年2月，94例患者前瞻性入组研究（平均年龄33.0岁;男性53.2%;平均病程56.7个月），包括56例（59.6%）溃疡性结肠炎和38例（40.4%）克罗恩病。在入组的94例患者中，15例（16.0%）发生IBD发作，79例（84.0%）在整个旅行期间保持缓解。Logistic回归分析显示，旅行前粪便钙卫蛋白水平高，（比值比[OR]：1.001，95%置信区间[CI]：1.000-1.001，p = 0.016），存在合并症（OR：6.334，95% CI：1.129-35.526，p = 0.036）和急诊室就诊史（OR：5.283，95% CI：1.085-25.724，p = 0.039）与疾病发作呈正相关。既往和当前使用免疫调节剂和生物制剂、飞行时间、海拔、访问国家数量、旅行时间、访问目的和既往医学咨询与疾病发作无关。粪便钙卫蛋白水平升高、急诊室就诊史和合并症的存在可预测国际航空旅行期间IBD的发作。
Inflammatory bowel disease (IBD) patients often experience disease flare-ups during international air travel. We aimed to identify risk factors associated with IBD flare-up during international air travel. Patients with scheduled international air travel were enrolled in the study from the Seoul National University Bundang Hospital IBD clinic. Flight information and clinical data were collected via questionnaires and personal interviews, and risk factors associated with IBD flares were determined. Between May 2018 and February 2020, 94 patients were prospectively enrolled in the study (mean age, 33.0 years; males, 53.2%; mean disease duration, 56.7 months), including 56 (59.6%) with ulcerative colitis and 38 (40.4%) with Crohn’s disease. Of the 94 patients enrolled, 15 (16.0%) experienced an IBD flare-up and 79 (84.0%) remained in remission throughout travel. Logistic regression analysis revealed that high fecal calprotectin levels before travel (odds ratio [OR]: 1.001, 95% confidence interval [CI]: 1.000–1.001, p = 0.016), the presence of a comorbidity (OR: 6.334, 95% CI: 1.129–35.526, p = 0.036), and history of emergency room visit (OR: 5.283, 95% CI: 1.085–25.724, p = 0.039) were positively associated with disease flare-up. The previous and current use of immunomodulators and biologics, time of flight, altitude, number countries visited, travel duration, objective of visit, and previous medical consultations were not associated with disease flare-up. Elevated fecal calprotectin levels, history of emergency room visits, and the presence of a comorbidity predicted IBD flare-up during international air travel.
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影响因子：
4.3
作者：
San Roman, Antonio Lopez;Munoz, Fernando
通讯作者：
Munoz, Fernando
溃疡性结肠炎。
DOI：
10.1016/s0140-6736(16)32126-2
发表时间：
2017-04-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Ungaro R;Mehandru S;Allen PB;Peyrin-Biroulet L;Colombel JF
通讯作者：
Colombel JF
影响因子：
12.6
作者：
Ben-Horin, Shomron;Bujanover, Yoram;Avidan, Benjamin
通讯作者：
Avidan, Benjamin
影响因子：
12.6
作者：
Bouguen, Guillaume;Levesque, Barrett G.;Sandborn, William J.
通讯作者：
Sandborn, William J.
影响因子：
12
作者：
van Aalst, Marielle;van Ruissen, Marella C. E.;Grobusch, Martin P.
通讯作者：
Grobusch, Martin P.