The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage.
The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage.
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慢性支气管炎和慢性气流阻塞对支气管肺泡灌洗恢复的肺细胞群的影响。
DOI：
10.1164/arrd.1985.132.2.254
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Springmeyer,SC
中科院分区：
文献类型：
--
作者：
Martin,TR;Raghu,G;Maunder,RJ;Springmeyer,SC
支气管肺泡灌洗用于评估弥漫性肺病患者的实质炎症。灌洗细胞计数和蛋白质的正常值主要来自没有肺部疾病的年轻受试者；然而，接受支气管肺泡灌洗的老年患者往往长期吸烟，并出现不同程度的慢性支气管炎和/或慢性气流阻塞。因此，我们通过对 48 名接受诊断性纤维支气管镜检查的男性患者进行支气管肺泡灌洗，评估了吸烟、慢性支气管炎和慢性气流阻塞对灌洗细胞群的影响。 16 名患者 (33%) 的灌洗液中中性粒细胞百分比升高 (⩾ 10%)。其中 14 人（87.5%）有慢性咳嗽和/或咳痰，但只有 9 人（64.3%）符合明确慢性支气管炎的标准。与轻度或无气流阻塞的患者相比，中度或重度气流阻塞（通过肺活量测定定义）患者的灌洗中性粒细胞百分比显着较高，而巨噬细胞百分比较低。第一份灌洗液含有最大比例的中性粒细胞和最小比例的巨噬细胞。在连续等分试样中，中性粒细胞的百分比下降，巨噬细胞的百分比增加。数据表明，在没有弥漫性肺实质疾病或感染的情况下，慢性咳嗽和/或产生痰以及慢性气流阻塞的患者支气管肺泡灌洗液中中性粒细胞的比例可能增加。在解释灌洗细胞分析时必须考虑这些变量。由于大多数中性粒细胞是在第一次灌洗等份中发现的，因此从细胞分析中排除第一次灌洗等份可能会减少这些变量的影响。
Bronchoalveolar lavage is used to evaluate parenchymal inflammation in patients with diffuse lung disease. Normal values for lavage cell counts and proteins are derived primarily from young subjects who are free from lung disease; however, older patients who undergo bronchoalveolar lavage often have used cigarettes for long periods of time and have developed variable degrees of chronic bronchitis and/or chronic air-flow obstruction. Therefore, we evaluated the effects of cigarette use, chronic bronchitis, and chronic air-flow obstruction on lavage cell populations by performing bronchoalveolar lavage in 48 male patients who were undergoing diagnostic fiberoptic bronchoscopy. Sixteen patients (33%) had elevated percentages of neutrophils (⩾ 10%) in lavage fluid. Fourteen of these (87.5%) had chronic cough and/or phlegm production, but only 9 (64.3%) met criteria for definite chronic bronchitis. Patients with moderate or severe air-flow obstruction, defined spirometrically, had significantly greater percentages of lavage neutrophils and lower percentages of macrophages than did patients with mild or no air-flow obstruction. The first lavage aliquot contained the greatest proportion of neutrophils and the smallest proportion of macrophages. The percentage of neutrophils declined and the percentage of macrophages increased in sequential aliquots. The data indicate that patients with chronic cough and/or phlegm production and chronic air-flow obstruction may have increased proportions of neutrophils in bronchoalveolar lavage fluid in the absence of diffuse parenchymal lung disease or infections. These variables must be taken into account when interpreting lavage cellular analyses. As most of the neutrophils are found in the first lavage aliquot, exclusion of the first lavage aliquot from the cellular analysis may reduce the effects of these variables.
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影响因子：
158.5
作者：
NIEWOEHNER, DE;KLEINERMAN, J;RICE, DB
通讯作者：
RICE, DB
纤维支气管肺泡灌洗在评估间质性肺疾病中的安全性。
影响因子：
9.6
作者：
I. Strumpf;M. Feld;M. Cornelius;B. Keogh;R. Crystal
通讯作者：
R. Crystal
感染在慢性支气管炎中的作用。
DOI：
10.1164/arrd.1976.113.4.465
发表时间：
1976
期刊：
The American review of respiratory disease
影响因子：
--
作者：
D. Gump;C. A. Phillips;B. Forsyth;K. Mcintosh;K. Lamborn;W. H. Stouch
通讯作者：
W. H. Stouch
当前吸烟者和戒烟者的外周气道形态。
DOI：
--
发表时间：
2015
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
J. Wright;L. Lawson;P. Paré;B. Wiggs;S. Kennedy;J. Hogg
通讯作者：
J. Hogg
正常人支气管免疫球蛋白和蛋白质：吸烟的影响。
DOI：
10.1164/arrd.1977.116.1.25
发表时间：
1977
期刊：
The American review of respiratory disease
影响因子：
--
作者：
G. Warr;R. Martin;P. Sharp;R. Rossen
通讯作者：
R. Rossen