Multiple metals predict prolactin and thyrotropin (TSH) levels in men.
Multiple metals predict prolactin and thyrotropin (TSH) levels in men.
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DOI：
10.1016/j.envres.2009.06.004
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发表时间：
2009-10
影响因子：
8.3
通讯作者：
Wirth, Julia J.
中科院分区：
文献类型：
--
作者：
Meeker, John D.;Rossano, Mary G.;Protas, Bridget;Diamond, Michael P.;Puscheck, Elizabeth;Daly, Douglas;Paneth, Nigel;Wirth, Julia J.
暴露于许多金属会影响神经内分泌和甲状腺信号，这可能会对发育，行为，新陈代谢，生殖和其他功能产生不利影响。本研究评估了男性参与环境对男性生殖健康影响的研究中，血液中金属浓度与血清催乳素（PRL）和促甲状腺激素（TSH）水平（多巴胺能和甲状腺功能的标志物）之间的关系。分析了219名男性的血液样本中11种金属的浓度和血清PRL和TSH水平。在校正年龄、BMI和吸烟的多元线性回归模型中，PRL与砷、镉、铜、铅、锰、钼和锌呈负相关，但与铬呈正相关。其中几种相关性（Cd、Pb、Mo）与人类或动物的有限研究一致，当在模型中额外考虑多种金属时，仍存在一些相关性（Cr、Cu、Pb、Mo）。铅和铜与TSH的非单调下降相关，而砷与TSH的剂量依赖性增加相关。对于砷，这些发现与最近的实验研究一致，其中砷抑制参与甲状腺激素合成和信号传导的酶。需要更多的研究来更好地了解金属在神经内分泌和甲状腺功能中的作用以及相关的健康影响。
Exposure to a number of metals can affect neuroendocrine and thyroid signaling, which can result in adverse effects on development, behavior, metabolism, reproduction, and other functions. The present study assessed the relationship between metal concentrations in blood and serum prolactin (PRL) and thyrotropin (TSH) levels, markers of dopaminergic and thyroid function, respectively, among men participating in a study of environmental influences on male reproductive health. Blood samples from 219 men were analyzed for concentrations of 11 metals and serum levels of PRL and TSH. In multiple linear regression models adjusted for age, BMI and smoking, PRL was inversely associated with arsenic, cadmium, copper, lead, manganese, molybdenum, and zinc, but positively associated with chromium. Several of these associations (Cd, Pb, Mo) are consistent with limited studies in humans or animals, and a number of the relationships (Cr, Cu, Pb, Mo) remained when additionally considering multiple metals in the model. Lead and copper were associated with non-monotonic decreases in TSH, while arsenic was associated with a dose-dependent increase in TSH. For arsenic these findings were consistent with recent experimental studies where arsenic inhibited enzymes involved in thyroid hormone synthesis and signaling. More research is needed for a better understanding of the role of metals in neuroendocrine and thyroid function and related health implications.
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与精液质量有关的镉，铅和其他金属：人类作为男性生殖毒物的人类证据。
影响因子：
10.4
作者：
Meeker, John D.;Rossano, Mary G.;Protas, Bridget;Diamond, Michael P.;Puscheck, Elizabeth;Daly, Douglas;Paneth, Nigel;Wirth, Julia J.
通讯作者：
Wirth, Julia J.
影响因子：
8.3
作者：
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通讯作者：
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影响因子：
3.9
作者：
Palazzolo, Dominic L.;Jansen, Kevin P.
通讯作者：
Jansen, Kevin P.
影响因子：
2.9
作者：
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通讯作者：
Lafond, J
影响因子：
8.3
作者：
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通讯作者：
Cvltkovic, Petar