The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation.
The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation.
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DOI：
10.1038/mp.2009.80
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发表时间：
2010-03
影响因子：
11
通讯作者：
中科院分区：
文献类型：
--
作者：
噻奈普汀是一种临床使用的抗抑郁药，因其挑战了传统的抑郁症单胺能假说而备受关注。现在公认，噻奈普汀的抗抑郁作用及其显着的临床耐受性可归因于其特殊的神经生物学特性。谷氨酸参与抗抑郁药噻奈普汀的作用机制与成熟的临床前文献一致，这些文献证明了谷氨酸在抑郁症状背后的神经可塑性改变机制中的关键作用。本文回顾了噻奈普汀作用机制的最新证据，重点关注谷氨酸能系统，该系统可能为其抗抑郁作用提供关键途径。一系列证据证明了噻奈普汀对谷氨酸能系统的作用，因此为噻奈普汀如何用于治疗抑郁症提供了新的见解。
Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key role of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine’s mechanism of action with a focus on the glutamatergic system which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders.
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