Incidence of and risk factors for dementia in the Ibadan study of aging.
Incidence of and risk factors for dementia in the Ibadan study of aging.
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DOI：
10.1111/j.1532-5415.2011.03374.x
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发表时间：
2011-05
影响因子：
6.3
通讯作者：
Abiona T
中科院分区：
文献类型：
--
作者：
Gureje O;Ogunniyi A;Kola L;Abiona T
描述尼日利亚约鲁巴老年人代表性样本中痴呆症的发病率，并提供有关危险因素的信息。对通过家庭多阶段整群抽样选出的社区队列进行了家庭面对面评估，基线在 2003 年 11 月至 2004 年 8 月之间（n = 2,149），并在大约 39 个月后进行随访（n = 1,408）。尼日利亚八个毗邻的、主要讲约鲁巴语的州。基线时 65 岁及以上未患痴呆症的人 (n = 1,225)。使用两种工具来确定痴呆症：10 词延迟回忆测试和临床医生家庭访谈来评估功能，这两种工具都具有经过验证的有效性和文化适用性。在 3 年的随访中，85 名参与者患上了痴呆症。样本共有 3,888 个风险年，估计痴呆发病率为每 1,000 人年 21.85 人（95% 置信区间 = 17.67–27.03）。与男性相比，女性的年龄调整风险比 (HR) 为 2.12 (P = .002)。发病率随年龄呈线性增加，因此，与 65 至 74 岁的参与者相比，75 至 84 岁参与者的 HR（按性别调整）为 2.84 (P<.001)，而 85 岁及以上参与者的 HR 为 4.13 (P<.001)。居住在农村地区和经济状况越差，痴呆症的发病率就越高。基线时社交参与度较差的参与者患痴呆症的风险明显更高。尼日利亚约鲁巴人的痴呆症发病率比之前报道的要高。社会孤立指数是该人群发生痴呆的危险因素。
To describe the incidence of dementia in a representative sample of elderly Yoruba Nigerians and provide information about the risk factors. In-home face-to-face assessments conducted on a community cohort selected using multistage clustered sampling of households, with baseline between November 2003 and August 2004 (n = 2,149) and follow-up approximately 39 months later (n = 1,408). Eight contiguous, predominantly Yoruba-speaking states in Nigeria. Persons aged 65 and older free of dementia at baseline (n = 1,225). Dementia was ascertained using two instruments: the 10-Word Delayed Recall Test and the Clinician Home-based Interview to assess Function, both with demonstrated validity and cultural applicability. At 3-year follow-up, 85 participants had developed dementia. With a total 3,888 risk years for the sample, the estimated incidence of dementia was 21.85 per 1,000 person-years (95% confidence interval = 17.67–27.03). Compared with men, the age-adjusted hazard ratio (HR) for women was 2.12 (P = .002). Incidence increased linearly with age such that, compared with participant aged 65 to 74, the HR, adjusted for sex, for participants aged 75 to 84 was 2.84 (P<.001) and for those aged 85 and older was 4.13 (P<.001). Greater incidence of dementia was found with more-rural residence and poorer economic status. Participants with poor social engagement at baseline were at significantly greater risk of incident dementia. Incident dementia in Yoruba Nigerians is higher than previously reported. Indices of social isolation are risk factors for incident dementia in this population.
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影响因子：
48
作者：
Kalaria, Raj N.;Maestre, Gladys E.;Arizaga, Raul;Friedland, Robert P.;Galasko, Doug;Hall, Kathleen;Luchsinger, Jose A.;Ogunniyi, Adesola;Perry, Elaine K.;Potocnik, Felix;Prince, Martin;Stewart, Robert;Wimo, Anders;Zhang, Zhen-Xin;Antuono, Piero
通讯作者：
Antuono, Piero
影响因子：
11.2
作者：
Gureje, O;Ogunniyi, A;Murrell, JR
通讯作者：
Murrell, JR
影响因子：
9.9
作者：
Chandra, V;Pandav, R;Ganguli, M
通讯作者：
Ganguli, M
影响因子：
--
作者：
Gao, S;Hendrie, HC;Hall, KS
通讯作者：
Hall, KS
影响因子：
4.8
作者：
Ineichen, Bernard
通讯作者：
Ineichen, Bernard