Asymmetric neural dynamics characterize loss and recovery of consciousness.
Asymmetric neural dynamics characterize loss and recovery of consciousness.
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DOI：
10.1016/j.neuroimage.2021.118042
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发表时间：
2021-08-01
期刊：
影响因子：
5.7
通讯作者：
Hudetz AG
中科院分区：
文献类型：
--
作者：
Huang Z;Tarnal V;Vlisides PE;Janke EL;McKinney AM;Picton P;Mashour GA;Hudetz AG
已知麻醉剂会破坏皮质和皮质下脑回路中的神经相互作用。虽然麻醉药物对意识的影响是可逆的，但介导诱导和恢复的神经机制可能不同。对这些不同机制的深入了解可以通过系统比较麻醉缓慢诱导和苏醒过程中的神经动力学来获得。为此，我们使用功能性磁共振成像（fMRI）数据在健康志愿者之前，期间和之后的丙泊酚在递增调整的目标浓度管理。我们分析了皮质和皮质下皮质网络的功能连接和功能磁共振成像信号的时间自相关作为神经处理时间尺度的指标。我们发现，在无意识的过程中，整个大脑的时间自相关性逐渐增加，而功能连接逐渐减少。相反，恢复意识与皮质时间自相关性的突然恢复有关，但与皮质下时间自相关性无关，与皮质下功能连接性的突然增强有关。药代动力学效应不能解释诱导和羽化之间的神经动力学差异。我们的结论是，诱导和恢复阶段的麻醉遵循不对称的神经动力学。皮质神经处理速度和皮质下神经相互作用的快速增加可能是重新启动意识的机制。
Anesthetics are known to disrupt neural interactions in cortical and subcortical brain circuits. While the effect of anesthetic drugs on consciousness is reversible, the neural mechanism mediating induction and recovery may be different. Insight into these distinct mechanisms can be gained from a systematic comparison of neural dynamics during slow induction of and emergence from anesthesia. To this end, we used functional magnetic resonance imaging (fMRI) data obtained in healthy volunteers before, during, and after the administration of propofol at incrementally adjusted target concentrations. We analyzed functional connectivity of corticocortical and subcorticocortical networks and the temporal autocorrelation of fMRI signal as an index of neural processing timescales. We found that en route to unconsciousness, temporal autocorrelation across the entire brain gradually increased, whereas functional connectivity gradually decreased. In contrast, regaining consciousness was associated with an abrupt restoration of cortical but not subcortical temporal autocorrelation and an abrupt boost of subcorticocortical functional connectivity. Pharmacokinetic effects could not account for the difference in neural dynamics between induction and emergence. We conclude that the induction and recovery phases of anesthesia follow asymmetric neural dynamics. A rapid increase in the speed of cortical neural processing and subcorticocortical neural interactions may be a mechanism that reboots consciousness.
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DOI：
10.1073/pnas.1011949107
发表时间：
2010-12-07
影响因子：
11.1
作者：
Breshears, Jonathan D.;Roland, Jarod L.;Leuthardt, Eric C.
通讯作者：
Leuthardt, Eric C.
影响因子：
64.5
作者：
Halassa MM;Chen Z;Wimmer RD;Brunetti PM;Zhao S;Zikopoulos B;Wang F;Brown EN;Wilson MA
通讯作者：
Wilson MA
影响因子：
2
作者：
Gillies MJ;Hyam JA;Weiss AR;Antoniades CA;Bogacz R;Fitzgerald JJ;Aziz TZ;Whittington MA;Green AL
通讯作者：
Green AL
影响因子：
16.6
作者：
Gao, S.;Proekt, A.;Pfaff, D. W.
通讯作者：
Pfaff, D. W.
影响因子：
5.7
作者：
Campbell, Justin M.;Huang, Zirui;Hudetz, Anthony G.
通讯作者：
Hudetz, Anthony G.