Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicenter study.
Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicenter study.
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哥伦比亚慢性和侵袭性牙周炎的人口、临床和微生物方面：一项多中心研究。
DOI：
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
R. Arce
中科院分区：
文献类型：
--
作者：
G. Lafaurie;A. Contreras;A. Barón;J. Botero;I. Mayorga;Adriana Jaramillo;Astrid Giraldo;Ferney González;Sergio Mantilla;A. Botero;L. Archila;A. Diaz;T. Chacón;D. Castillo;M. Betancourt;Maria Del Rosario Aya;R. Arce
背景
牙周病的微生物谱在不同的人群中有所不同。这项研究在哥伦比亚的一个多地理样本中评估了牙周炎的人口统计学、临床和微生物学方面。
方法
对来自全国5个地区的325例慢性牙周炎患者、158例侵袭性牙周炎患者和137例健康牙周炎患者进行了研究。收集了临床、微生物和社会人口学数据。用聚合酶链式反应16S rRNA基因对收集的龈下标本进行微生物鉴定，并通过培养鉴定革兰氏阴性肠杆菌的存在。进行双因素和多因素Logistic回归分析。
结果
牙周炎患者中71.5%为牙龈卟啉单胞菌，58.5%为金黄色葡萄球菌，57.5%为直肠弯曲杆菌，23.6%为伴生放线放线杆菌，34.5%为肠道杆状杆菌。牙龈假单胞菌在慢性前列腺炎和急性牙周炎患者中比对照组更常见。与对照组和CP患者相比，AGP患者伴生放线菌数量增加。在西太平洋和中部地区，台湾血吸虫、直肠弯曲杆菌和艾美耳球虫的腐蚀性较低，中部地区的肠道细菌数量较多(P<；0.05)。其他社会人口学因素与这些微生物无关。
结论
地理区域不影响微生物区系，但微生物区系可能因地理区域而异。在哥伦比亚，牙龈假单胞菌、福氏支原体和直链球菌是最流行的牙周致病微生物。放线菌伴生菌在AGP中更常见，研究人群中有很大比例的人在龈下菌斑中有肠道杆状杆菌。
BACKGROUND
The microbial profile of periodontal disease varies among different human populations. This study evaluated the demographic, clinical, and microbiologic aspects of periodontitis in a multigeographic sample in Colombia.
METHODS
Three hundred twenty-five patients with chronic periodontitis (CP), 158 patients with aggressive periodontitis (AgP), and 137 healthy-gingivitis controls from five regions of the country were studied. Clinical, microbial, and sociodemographic data were collected. Microbiologic identification was performed using polymerase chain reaction 16S rRNA gene on pooled subgingival samples, and the presence of Gram-negative enteric rods was evaluated by culture. Bivariate and multivariate logistic regression analyses were conducted.
RESULTS
Porphyromonas gingivalis occurred in 71.5% of individuals with periodontitis, Tannerella forsythensis occurred in 58.5%, Campylobacter rectus occurred in 57.5%, Actinobacillus actinomycetemcomitans occurred in 23.6%, and enteric rods occurred in 34.5%. P. gingivalis was more common in CP and AgP than controls. A. actinomycetemcomitans was increased in AgP compared to controls and patients with CP. T. forsythensis, C. rectus, and Eikenella corrodens had a low presence in the West Pacific and Central regions, and enteric rods were increased in the Central region (P <0.05). Other sociodemographic factors were not associated with these microorganisms.
CONCLUSIONS
Geographic regions do not influence the microbiota, but the microbiota may vary by geographic region. P. gingivalis, T. forsythensis, and C. rectus are the most prevalent periodontophatic microorganisms in Colombia. A. actinomycetemcomitans was more common in AgP, and a large percentage of the population studied had enteric rods in the subgingival plaque.
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