The Human Cutaneous Sensory Corpuscles: An Update.
The Human Cutaneous Sensory Corpuscles: An Update.
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DOI：
10.3390/jcm10020227
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发表时间：
2021-01-10
影响因子：
3.9
通讯作者：
Vega JA
中科院分区：
文献类型：
--
作者：
Cobo R;García-Piqueras J;Cobo J;Vega JA
人皮肤的感觉小体是与作为低阈值机械感受器的非神经元细胞相关的初级机械感受神经元的末梢。在结构上，它们包括一个mechanosensory轴突和nonmyelinating外周神经胶质细胞的极端尖端，根据感觉小体的形态型排列，所有覆盖的神经内膜和/或神经束膜起源的结缔细胞。虽然敏感小体的病理是罕见的，几乎从来没有严重的，足够的知识的结构和免疫组化的这些形成是必不可少的皮肤科医生和病理学家。事实上，由于感觉小体和神经共享基本结构和蛋白质组成，皮肤活检可能是分析周围神经病变、全身性疾病和中枢神经系统的几种病理中神经受累的补充方法。因此，皮肤感觉小体的活组织检查可以为它们所涉及的某些病理的诊断、演变和治疗有效性提供信息。本文就感觉小体免疫组织化学的研究进展作一综述，以期为皮肤科医生和皮肤病理学家提供参考。
Sensory corpuscles of human skin are terminals of primary mechanoreceptive neurons associated with non-neuronal cells that function as low-threshold mechanoreceptors. Structurally, they consist of an extreme tip of a mechanosensory axon and nonmyelinating peripheral glial cells variably arranged according to the morphotype of the sensory corpuscle, all covered for connective cells of endoneurial and/or perineurial origin. Although the pathologies of sensitive corpuscles are scarce and almost never severe, adequate knowledge of the structure and immunohistochemical profile of these formations is essential for dermatologists and pathologists. In fact, since sensory corpuscles and nerves share a basic structure and protein composition, a cutaneous biopsy may be a complementary method for the analysis of nerve involvement in peripheral neuropathies, systemic diseases, and several pathologies of the central nervous system. Thus, a biopsy of cutaneous sensory corpuscles can provide information for the diagnosis, evolution, and effectiveness of treatments of some pathologies in which they are involved. Here, we updated and summarized the current knowledge about the immunohistochemistry of human sensory corpuscles with the aim to provide information to dermatologists and skin pathologists.
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影响因子：
5.6
作者：
Cobo R;García-Piqueras J;García-Mesa Y;Feito J;García-Suárez O;Vega JA
通讯作者：
Vega JA
影响因子：
1.1
作者：
Cano Garcia, Fernando;Rodriguez Acosta, Dalia;Saeb Lima, Marcela
通讯作者：
Saeb Lima, Marcela
DOI：
10.1002/ar.24328
发表时间：
2019-12-26
影响因子：
2
作者：
Garcia-Piqueras, Jorge;Garcia-Suarez, Olivia;Vega, Jose A.
通讯作者：
Vega, Jose A.
DOI：
10.1002/ar.23951
发表时间：
2019-02-01
影响因子：
2
作者：
Garcia-Piqueras, Jorge;Carcaba, Lucia;Garcia-Suarez, Olivia
通讯作者：
Garcia-Suarez, Olivia
影响因子：
2.2
作者：
Feito, J.;Garcia-Suarez, O.;Vega, J. A.
通讯作者：
Vega, J. A.