Subfunctionalization of duplicated genes as a transition state to neofunctionalization.
Subfunctionalization of duplicated genes as a transition state to neofunctionalization.
复制标题
重复基因作为新功能化的过渡状态的亚功能化。
DOI：
10.1186/1471-2148-5-28
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发表时间：
2005-04-14
影响因子：
3.4
通讯作者：
Liberles, DA
中科院分区：
文献类型：
--
作者：
Rastogi, S;Liberles, DA
基因复制被认为是进化新颖性产生的一个重要过程。新功能化是一种适应性过程，其中一个拷贝突变为复制前基因中不存在的功能，是一种可以导致两个拷贝保留的机制。最近，亚功能化作为两个拷贝划分祖先功能的中性过程，被提议作为驱动有效群体规模较小的生物体中重复基因保留的替代机制。这两个过程的相对重要性尚不清楚。设计了一组晶格模型基因，这些基因折叠并结合具有重叠结合袋的两个肽配体，但细胞中不存在第三个配体。每个基因在一个模型单倍体物种中复制，该物种具有较小的恒定种群规模并且没有重组。一组模型允许在复制后对绑定事件进行子功能化，而另一组则不允许子功能化。在这种条件下的建模表明，亚功能化发挥着重要作用，但它是作为新功能化的过渡状态，而不是作为重复基因的最终命运。不存在维持冗余的明显选择压力。亚功能化导致重复基因拷贝的保存增加，包括那些新功能化的基因拷贝，但在任何进化时间点都不会代表重复基因拷贝的大部分，并最终导致这些保存的拷贝的新功能化。这一结论也可能反映了真实基因组中复制后基因功能随时间的变化。
Gene duplication has been suggested to be an important process in the generation of evolutionary novelty. Neofunctionalization, as an adaptive process where one copy mutates into a function that was not present in the pre-duplication gene, is one mechanism that can lead to the retention of both copies. More recently, subfunctionalization, as a neutral process where the two copies partition the ancestral function, has been proposed as an alternative mechanism driving duplicate gene retention in organisms with small effective population sizes. The relative importance of these two processes is unclear. A set of lattice model genes that fold and bind to two peptide ligands with overlapping binding pockets, but not a third ligand present in the cell was designed. Each gene was duplicated in a model haploid species with a small constant population size and no recombination. One set of models allowed subfunctionalization of binding events following duplication, while another set did not allow subfunctionalization. Modeling under such conditions suggests that subfunctionalization plays an important role, but as a transition state to neofunctionalization rather than as a terminal fate of duplicated genes. There is no apparent selective pressure to maintain redundancy. Subfunctionalization results in an increase in the preservation of duplicated gene copies, including those that are neofunctionalized, but never represents a substantial fraction of duplicate gene copies at any evolutionary time point and ultimately leads to neofunctionalization of those preserved copies. This conclusion also may reflect changes in gene function after duplication with time in real genomes.
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影响因子：
30.8
作者：
McLysaght, A;Hokamp, K;Wolfe, KH
通讯作者：
Wolfe, KH
影响因子：
56.9
作者：
Lynch, M;Conery, JS
通讯作者：
Conery, JS
DOI：
10.1002/prot.10016
发表时间：
2002-01-01
期刊：
PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子：
--
作者：
Taverna, DM;Goldstein, RA
通讯作者：
Goldstein, RA
DOI：
10.1016/s0141-8130(03)00059-x
发表时间：
2003-11-01
影响因子：
8.2
作者：
Braun, FN;Liberles, DA
通讯作者：
Liberles, DA
影响因子：
2.9
作者：
Williams, PD;Pollock, DD;Goldstein, RA
通讯作者：
Goldstein, RA