CART peptides: regulators of body weight, reward and other functions.

CART peptides: regulators of body weight, reward and other functions.
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DOI:
10.1038/nrn2493
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发表时间:
2008-10
期刊:
Nature reviews. Neuroscience
影响因子:
--
通讯作者:
Kuhar MJ
Kuhar MJ
中科院分区:
其他
文献类型:
--
作者:
Rogge G;Jones D;Hubert GW;Lin Y;Kuhar MJ

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在过去的十年左右,CART(可卡因和安非他明调节转录)肽已成为主要的神经递质和激素。CART肽广泛分布于中枢神经系统,参与调节许多过程,包括食物摄入、体重维持、奖励和内分泌功能。最近的研究已经提供了大量关于CART肽的定位、调控、加工和功能的信息,但还需要进一步的研究来阐明这些肽的生理作用和表征CART受体,以利用可能的治疗应用。
Over the past decade or so, CART (cocaine- and amphetamine-regulated transcript) peptides have emerged as major neurotransmitters and hormones. CART peptides are widely distributed in the CNS and are involved in regulating many processes, including food intake and the maintenance of body weight, reward and endocrine functions. Recent studies have produced a wealth of information about the location, regulation, processing and functions of CART peptides, but additional studies aimed at elucidating the physiological effects of the peptides and at characterizing the CART receptor(s) are needed to take advantage of possible therapeutic applications.
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