Neural correlates of stress-induced and cue-induced drug craving: influences of sex and cocaine dependence.
Neural correlates of stress-induced and cue-induced drug craving: influences of sex and cocaine dependence.
复制标题
DOI：
10.1176/appi.ajp.2011.11020289
复制
发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Sinha R
中科院分区：
文献类型：
--
作者：
Potenza MN;Hong KI;Lacadie CM;Fulbright RK;Tuit KL;Sinha R
虽然压力和药物线索暴露每个增加药物渴望，并有助于复发可卡因依赖，没有以前的研究直接检查可卡因依赖的妇女和男子相对于比较科目的神经相关的压力和药物线索诱导的渴望。功能磁共振成像被用来评估反应的个性化脚本的压力，药物/酒精线索和中性放松意象条件下，在30个禁欲可卡因依赖的个人（16名妇女，14名男子）和36个健康的娱乐饮酒比较科目（18名妇女，18名男子）。诊断组，性别和脚本条件之间的显着的三向相互作用，观察到在多个大脑区域，包括纹状体，纹状体，前扣带回和后扣带回。在妇女中，组由条件的相互作用，观察到涉及这些地区，并归因于相对增加的区域激活可卡因依赖的妇女在压力，并在较小程度上，中性放松条件。在男性中，观察到涉及这些相同区域的组主效应，可卡因依赖男性在各种条件下表现出相对增加的激活，主要来自药物和中性放松条件。在男性和女性中，主观药物诱导的渴望措施与皮质纹状体边缘系统激活呈正相关。在可卡因依赖中，皮质-纹状体边缘功能亢进似乎与女性的压力线索、男性的药物线索以及两者的中性放松条件有关。这些研究结果表明，在选择治疗成瘾的疗法时，应考虑到性别，特别是那些以减轻压力为目标的疗法。
Although stress and drug cue exposure each increase drug craving and contribute to relapse in cocaine dependence, no previous research has directly examined the neural correlates of stress-induced and drug cue-induced craving in cocaine-dependent women and men relative to comparison subjects. Functional MRI was used to assess responses to individualized scripts for stress, drug/alcohol cue and neutral-relaxing-imagery conditions in 30 abstinent cocaine-dependent individuals (16 women, 14 men) and 36 healthy recreational-drinking comparison subjects (18 women, 18 men). Significant three-way interactions between diagnostic group, sex, and script condition were observed in multiple brain regions including the striatum, insula, and anterior and posterior cingulate. Within women, group-by-condition interactions were observed involving these regions and were attributable to relatively increased regional activations in cocaine-dependent women during the stress and, to a lesser extent, neutral-relaxing conditions. Within men, group main effects were observed involving these same regions, with cocaine-dependent men demonstrating relatively increased activation across conditions, with the main contributions from the drug and neutral-relaxing conditions. In men and women, subjective drug-induced craving measures correlated positively with corticostriatal-limbic activations. In cocaine dependence, corticostriatal-limbic hyperactivity appears to be linked to stress cues in women, drug cues in men, and neutral-relaxing conditions in both. These findings suggest that sex should be taken into account in the selection of therapies in the treatment of addiction, particularly those targeting stress reduction.
登录
查看更多内容
DOI：
10.1098/rstb.2009.0147
发表时间：
2010-01-27
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Clark L
通讯作者：
Clark L
影响因子：
--
作者：
Kilts, CD;Schweitzer, JB;Drexler, KPG
通讯作者：
Drexler, KPG
慢性可卡因自我给药的禁欲改变了恒河猴中的纹状体多巴胺系统。
DOI：
10.1038/npp.2008.135
发表时间：
2009-04
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Hampshire A;Chamberlain SR;Monti MM;Duncan J;Owen AM
通讯作者：
Owen AM
影响因子：
3.5
作者：
Brewer JA;Sinha R;Chen JA;Michalsen RN;Babuscio TA;Nich C;Grier A;Bergquist KL;Reis DL;Potenza MN;Carroll KM;Rounsaville BJ
通讯作者：
Rounsaville BJ