Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
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DOI：
10.1371/journal.pone.0039955
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kanba S
中科院分区：
文献类型：
--
作者：
Oda Y;Onitsuka T;Tsuchimoto R;Hirano S;Oribe N;Ueno T;Hirano Y;Nakamura I;Miura T;Kanba S
据报道，周期性的听觉点击刺激可引发听觉稳态反应（ASSR）。 ASSR 被认为可以反映 γ-氨基丁酸 (GABA) 抑制神经元间活性的效率。尽管之前已经提出 GABA 能功能障碍的潜在作用，但双相情感障碍 (BD) 患者 ASSR 中神经同步的作用很少受到关注。在当前的研究中，我们研究了 BD 患者对 20 Hz、30 Hz、40 Hz 和 80 Hz 咔嗒声的 ASSR。共有 14 名 BD 患者（4 名男性）和 25 名健康对照者（10 名男性）参与了这项研究。使用全头 306 通道脑磁图计算 ASSR 功率值和锁相因子 (PLF) 来获得 ASSR。 BD 患者在 30、40 和 80 Hz 频率下表现出双侧平均 ASSR 功率和 PLF 值显着降低（这些频率的 p<0.05）。在 20 Hz 频率下，双相情感障碍患者的平均 ASSR 功率和 PLF 值没有显着降低。从右半球获得的 80 Hz-ASSR 功率值与汉密尔顿抑郁评定量表得分之间存在显着负相关（rho = −0.86，p = 0.0003）。目前的研究表明，BD 患者的双侧低和高伽玛波段 ASSR 功率和 PLF 均有所降低，而 β 波段 ASSR 没有显着降低。 BD 患者的特点是伽玛带振荡缺陷，这可能与 GABA 抑制性神经元间活动功能障碍有关。
Periodic auditory click stimulation has been reported to elicit an auditory steady state response (ASSR). The ASSR has been suggested to reflect the efficiency of γ-amino butyric acid (GABA) inhibitory interneuronal activity. Although a potential role for GABAergic dysfunction has been previously proposed, the role of neural synchronization in the ASSR in people with bipolar disorder (BD) has received little attention. In the current study, we investigated ASSRs to 20 Hz, 30 Hz, 40 Hz and 80 Hz click trains in BD patients. A total of 14 (4 males) BD patients and 25 (10 males) healthy controls participated in this study. ASSRs were obtained using whole-head 306-channel magnetoencephalography to calculate, ASSR power values and phase locking factors (PLF). BD patients exhibited significantly reduced mean ASSR power and PLF values bilaterally at frequencies of 30, 40, and 80 Hz (p<0.05 for these frequencies). At 20 Hz, bipolar patients showed no significant reduction in mean ASSR power and PLF values. There was a significant negative correlation between 80 Hz-ASSR-power values obtained from the right hemisphere and scores on the Hamilton Depression Rating Scale (rho = −0.86, p = 0.0003). The current study showed reduced low and high gamma band ASSR power and PLF bilaterally with no significant beta band ASSR reduction in BD patients. BD patients are characterized by deficits in gamma band oscillations, which may be associated with GABA inhibitory interneuronal activity dysfunction.
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影响因子：
5.4
作者：
Rass O;Krishnan G;Brenner CA;Hetrick WP;Merrill CC;Shekhar A;O'Donnell BF
通讯作者：
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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