Auditory steady state response in bipolar disorder: relation to clinical state, cognitive performance, medication status, and substance disorders.
Auditory steady state response in bipolar disorder: relation to clinical state, cognitive performance, medication status, and substance disorders.
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躁郁症中的听觉稳态反应：与临床状态，认知性能，药物状况和物质疾病的关系。
DOI：
10.1111/j.1399-5618.2010.00871.x
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发表时间：
2010-12
影响因子：
5.4
通讯作者：
O'Donnell BF
中科院分区：
文献类型：
--
作者：
Rass O;Krishnan G;Brenner CA;Hetrick WP;Merrill CC;Shekhar A;O'Donnell BF
双相情感障碍患者的听觉稳态反应（ASSR）在γ频率范围内异常，但这些神经生理障碍与临床因素的关系尚未得到很好的表征。因此，我们评估了ASSR在双相情感障碍，并检查其敏感性的临床症状，认知功能和药物治疗。共有68名双相情感障碍患者和77名对照参与者进行了评估。在20、30、40和50 Hz诱发ASSR时呈现咔哒声串。平均试验功率（MTP）和锁相因子（PLF）测量每个刺激频率下ASSR的反应幅度和相位同步性。评估临床状态、药物治疗和神经心理学表现，并评价其各自与ASSR测量的关系。与对照组相比，双相情感障碍患者的MTP和PLF降低。服用精神药物的双相情感障碍患者的PLF相对于停用药物的患者降低。对照组参与者在神经心理学测试中的表现优于双相情感障碍患者;然而，测试分数与ASSR测量无关。双相情感障碍患者ASSR的产生和维持存在缺陷，提示听觉通路紊乱。ASSR可能对药物状态敏感。其他临床特征，包括情绪状态、精神病特征、认知能力、吸烟或物质使用障碍史，与MTP或PLF无关。
Abnormalities in auditory steady state response (ASSR) at gamma range frequencies have been found in bipolar disorder, but the relationship of these neurophysiological disturbances to clinical factors has not been well characterized. We therefore evaluated the ASSR in bipolar disorder and examined its sensitivity to clinical symptoms, cognitive function, and pharmacological treatment. A total of 68 patients with bipolar disorder and 77 control participants were evaluated. Click trains presented at 20, 30, 40, and 50 Hz evoked ASSRs. Mean trial power (MTP) and phase locking factor (PLF) measured response magnitude and phase synchronization of the ASSR at each stimulation frequency. Clinical state, pharmacological treatment, and neuropsychological performance were assessed, and their respective relationships with ASSR measures were evaluated. Patients with bipolar disorder showed reduced MTP and PLF compared to control participants. Bipolar disorder patients taking psychotropic medications had decreased PLF relative to patients withdrawn from medications. Control participants performed better on neuropsychological tests than bipolar disorder patients; however, test scores did not correlate with ASSR measures. Deficits in the generation and maintenance of ASSR are present in bipolar disorder, implicating disturbances in auditory pathways. ASSR may be sensitive to medication status. Other clinical features, including mood state, psychotic features, cognitive performance, smoking, or history of substance use disorder, were unrelated to MTP or PLF.
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影响因子：
2.5
作者：
Chen, HH;Nicoletti, MA;Soares, JC
通讯作者：
Soares, JC
影响因子：
6.6
作者：
Berk, Michael;Ng, Felicity;Tohen, Mauricio
通讯作者：
Tohen, Mauricio
影响因子：
5.4
作者：
Carroll, Christine A.;Kieffaber, Paul D.;Hetrick, William P.
通讯作者：
Hetrick, William P.
影响因子：
6.9
作者：
Hall, Mei-Hua;Rijsdijk, Fruhling;Murray, Robin M.
通讯作者：
Murray, Robin M.
影响因子：
4.6
作者：
Hayden, Elizabeth P.;Bodkins, Misty;Hetrick, William P.
通讯作者：
Hetrick, William P.