Suppressive modulation of host immune responses by Dermanyssus gallinae infestation.
Suppressive modulation of host immune responses by Dermanyssus gallinae infestation.
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DOI：
10.1016/j.psj.2023.102532
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发表时间：
2023-04
期刊：
影响因子：
4.4
通讯作者：
Ohashi, Kazuhiko
中科院分区：
文献类型：
--
作者：
Fujisawa, Sotaro;Murata, Shiro;Isezaki, Masayoshi;Win, Shwe Yee;Sato, Takumi;Oishi, Eiji;Taneno, Akira;Maekawa, Naoya;Okagawa, Tomohiro;Konnai, Satoru;Ohashi, Kazuhiko
禽红螨（Dermanyssus gallinae， PRM）是鸡体内的一种吸血外寄生虫，是对家禽养殖场的最严重威胁之一。PRMs的大规模侵染会给鸡带来各种健康问题，导致家禽业的生产力显著下降。寄生有吸血外寄生虫，如蜱虫，会引起宿主的炎症和止血反应。另一方面，一些研究报道了噬血体外寄生虫从唾液中分泌各种免疫抑制剂来抑制宿主免疫反应以维持吸血。在这里，我们检测了外周血细胞因子的表达，以研究PRM感染是否会影响鸡的免疫状态。在prm感染的鸡中，抗炎细胞因子IL-10和TGF-β1以及免疫检查点分子CTLA-4和PD-1的表达高于未感染的鸡。prm衍生的可溶性螨提取物（SME）上调鸡外周血细胞和HD-11巨噬细胞中IL-10基因的表达。此外，SME还能抑制HD-11鸡巨噬细胞中干扰素和炎症因子的表达。此外，SME诱导巨噬细胞极化为抗炎表型。综上所述，PRM侵染可以影响宿主的免疫反应，特别是抑制炎症反应。为了充分了解PRM侵染对宿主免疫的影响，需要进一步的研究。
The poultry red mite (Dermanyssus gallinae, PRM) is a blood-sucking ectoparasite in chickens and is one of the most serious threats to poultry farms. Mass infestation with PRMs causes various health problems in chickens, resulting in significant productivity reduction in the poultry industry. Infestation with hematophagous ectoparasites, such as ticks, induces host inflammatory and hemostatic reactions. On the other hand, several studies have reported that hematophagous ectoparasites secrete various immunosuppressants from their saliva to suppress host immune responses to maintain blood sucking. Here, we examined the expression of cytokines in peripheral blood cells to investigate whether PRM infestation affects immunological states in chickens. In PRM-infested chickens, anti-inflammatory cytokines, IL-10 and TGF-β1, and immune checkpoint molecules, CTLA-4 and PD-1, were highly expressed compared to noninfested chickens. PRM-derived soluble mite extracts (SME) upregulated the gene expression of IL-10 in peripheral blood cells and HD-11 chicken macrophages. In addition, SME suppressed the expression of interferons and inflammatory cytokines in HD-11 chicken macrophages. Moreover, SME induces the polarization of macrophages into anti-inflammatory phenotypes. Collectively, PRM infestation could affect host immune responses, especially suppress the inflammatory responses. Further studies are warranted to fully understand the influence of PRM infestation on host immunity.
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影响因子：
--
作者：
Nunn F;Bartley K;Palarea-Albaladejo J;Nisbet AJ
通讯作者：
Nisbet AJ
影响因子：
3.5
作者：
Hardbower, Dana M.;Asim, Mohammad;Murray-Stewart, Tracy;Casero, Robert A., Jr.;Verriere, Thomas;Lewis, Nuruddeen D.;Chaturvedi, Rupesh;Piazuelo, M. Blanca;Wilson, Keith T.
通讯作者：
Wilson, Keith T.
影响因子：
3.3
作者：
Kotál J;Langhansová H;Lieskovská J;Andersen JF;Francischetti IM;Chavakis T;Kopecký J;Pedra JH;Kotsyfakis M;Chmelař J
通讯作者：
Chmelař J
影响因子：
3.2
作者：
Chen, Gang;Severo, Maiara S.;Pedra, Joao H. F.
通讯作者：
Pedra, Joao H. F.
DOI：
10.1016/s1050-3862(99)00017-0
发表时间：
1999-11-01
期刊：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Barriga, OO
通讯作者：
Barriga, OO