Non-monotonic relationships between arsenic and selenium excretion and its implication on arsenic methylation pattern in a Bangladeshi population.
Non-monotonic relationships between arsenic and selenium excretion and its implication on arsenic methylation pattern in a Bangladeshi population.
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孟加拉国人群砷和硒排泄之间的非单调关系及其对砷甲基化模式的影响。
DOI：
10.1016/j.envres.2015.03.019
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发表时间：
2015
影响因子：
8.3
通讯作者：
C.
中科院分区：
文献类型：
--
作者：
Yoshida;N.;Inaoka. T.;Sultana;N;Ahmad;S.A.;Mabuchi;A.;Shimizu;H.;Watanabe;C.
砷的毒性在个体和人群之间存在显着差异，这可能与无机砷（As）的代谢（甲基化）以及硒（Se）的营养状况有关。对生活在孟加拉国砷污染地区的成年人 (n=128) 进行了砷 (u-As) 和硒 (u-Se) 尿液排泄量的检查。尽管 u-Se 和 u-As 之间存在显着的负相关性（中位数 137；范围 49–927 µg/g 肌酐），但仔细检查发现它们之间存在非单调关系。以 As 轴为 155 μg/g Cre 的二次曲线给出了更好的拟合，u-As 和 u-Se 呈正相关或负相关，具体取决于 As 浓度是否低于或高于 155 μg As/g Cre。同样，As 甲基化模式与谷胱甘肽-S-转移酶 (GST) 多态性、体重指数 (BMI) 和 u-Se 之间的关系也因 u-As 范围而异。即高于或低于 155 µg/g Cre。尽管我们没有确定这些观察结果的因果机制，但砷暴露与所检查的变量之间的非单调关系表明存在一个阈值，在该阈值下，人体对砷的处理发生了质的变化。还讨论了硒营养对砷毒性的可能重要性。
The toxicity of arsenic differs markedly between individuals and populations, which might be related to the metabolism (methylation) of inorganic arsenic (As), as well as the selenium (Se) nutritional status. Urinary excretion of As (u-As) and Se (u-Se) was examined in an adult population (n=128) living in an As-contaminated area in Bangladesh. Although there was a significant negative correlation between u-Se and u-As (median 137; range 49–927 μg/g creatinine), closer examination revealed a non-monotonous relationship between them. A quadratic curve with an axis of As at 155 μg/g Cre gave a better fit, and u-As and u-Se were positively or negatively correlated depending on whether the As concentration was lower or higher than 155 μg As/g Cre, respectively. Likewise, the relationships between the As methylation pattern and glutathione-S-transferase (GST) polymorphism, body mass index (BMI), and u-Se differed depending on the u-As range; i.e., higher or lower than 155 μg/g Cre. Although we did not determine the causal mechanism for these observations, the non-monotonic relationship between As exposure and the variables examined suggested the existence of a threshold at which the handling of As by human body is qualitatively changed. The possible importance of Se nutrition for As toxicity is also discussed.
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影响因子：
8.3
作者：
Christian, WJ;Hopenhayn, C;Todorov, T
通讯作者：
Todorov, T
影响因子：
3.8
作者：
Watanabe, C;Kawata, A;Ohtsuka, R
通讯作者：
Ohtsuka, R
孟加拉国砷污染地区居民尿硒与砷水平呈负相关
影响因子：
--
作者：
Kaori Miyazaki;Kayo Ushijima;Takefumi Kadono;T. Inaoka;C. Watanabe;R. Ohtsuka
通讯作者：
R. Ohtsuka
GST 基因型与口腔鳞状细胞癌发病年龄和淋巴结转移的关系。
影响因子：
3.3
作者：
Chung;Che‐Shoa Chang;Man;C. Dang;Y. Shih;Kuo
通讯作者：
Kuo
影响因子：
4.1
作者：
Zakharyan, RA;Sampayo-Reyes, A;Aposhian, HV
通讯作者：
Aposhian, HV