HPV infection and triple-negative breast cancers: an Italian case-control study.
HPV infection and triple-negative breast cancers: an Italian case-control study.
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DOI：
10.1186/s12985-014-0190-3
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发表时间：
2014-11-21
期刊：
影响因子：
4.8
通讯作者：
De Miglio MR
中科院分区：
文献类型：
--
作者：
Piana AF;Sotgiu G;Muroni MR;Cossu-Rocca P;Castiglia P;De Miglio MR
乳腺癌是女性中最重要的肿瘤之一。为了减少其发病率和死亡率的影响，最好及早查明与其发展有关的危险因素。最近有人提出，生物制剂可能是病因，特别是人乳头瘤病毒（HPV）。到目前为止，还没有发现与不同类型乳腺癌之间的具体关系。特别是，以受体阴性模式（ER/PgR/ her2阴性）和预后差为特征的三阴性乳腺癌（TNBC），可以代表观察性研究中最相关的临床和公共卫生重点之一。该研究的目的是评估意大利北撒丁岛两种乳腺癌系列（TNBC与非TNBC）中hpv阳性的患病率。每组的样本量用40个福尔马林固定和石蜡包埋的标本来表示。平均年龄60.3岁。大多数肿瘤为导管癌（84%）。分级分布不同：G2在非TNBC系列中最常见，而G3在TNBC系列中最常见（分别为70%和72%）。6份生物样本hpv阳性（7.5%）：阳性仅在TNBC组评估（15%，p值：0.026）。分离的基因型分别为：16、31、45、52、6和66。仅发现1例合并感染（即HPV-6和-66）。TNBC标本中hpv阳性的患病率为15%。根据其致癌性，可以推测其在肿瘤发病中的病原学作用。这种关联应该通过纵向研究来证实，以更好地评估HPV感染在TNBC和非TNBC肿瘤中的作用。
Breast cancer is one of the most important neoplasia among women. To reduce its incidence and mortality impact it would be desirable to early identify risk factors associated with its development. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). No specific relationship with different breast cancer types has been demonstrated until now. In particular, the triple-negative breast cancer (TNBC), characterized by a receptor negative pattern (ER/PgR/HER2–negative) and poor prognosis, can represent one of the most relevant clinical and public health priority in terms of observational research. Aim of the study was to evaluate the HPV-positivity prevalence in two breast cancer series (TNBC vs. non-TNBC) in Northern Sardinia, Italy. The sample size of each group was represented by 40 formalin-fixed and paraffin-embedded specimens. The mean age was 60.3 years. The majority of the cancers were ductal (84%). The grading distribution was different: G2 was the most prevalent grade in the non-TNBC series, whereas G3 was the most frequent in the TNBC series (70% and 72%, respectively). Six biological samples were HPV-positive (7.5%): the positivity was assessed only in the TNBC group (15%; p-value: 0.026). The isolated genotypes were: 16, 31, 45, 52, 6, and 66. Only one co-infection was found (i.e., HPV-6 and -66). The prevalence of HPV-positivity in TNBC specimens was 15%. On the basis of its carcinogenetic ability, an etiological role in the pathogenesis of the cancer could be supposed. This association should be confirmed with longitudinal studies to better assess the role of the HPV infection in TNBC and non-TNBC tumors.
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影响因子：
2.8
作者：
Mammas, Ioannis N.;Sourvinos, George;Spandidos, Demetrios A.
通讯作者：
Spandidos, Demetrios A.
影响因子：
3.8
作者：
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通讯作者：
MARCANTE, ML
影响因子：
3.7
作者：
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通讯作者：
Chabay, Paola
影响因子：
8.8
作者：
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通讯作者：
Al Moustafa, A-E
影响因子：
3.7
作者：
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通讯作者：
Yamamoto N