Preparation of quantum dot/drug nanoparticle formulations for traceable targeted delivery and therapy.
Preparation of quantum dot/drug nanoparticle formulations for traceable targeted delivery and therapy.
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DOI：
10.7150/thno.3692
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发表时间：
2012
期刊：
影响因子：
12.4
通讯作者：
Reynolds JL
中科院分区：
文献类型：
--
作者：
Yong KT;Wang Y;Roy I;Rui H;Swihart MT;Law WC;Kwak SK;Ye L;Liu J;Mahajan SD;Reynolds JL
量子点(QD)是一种发光纳米晶体，具有丰富的表面化学和独特的光学性质，使其成为可追踪的靶向传递和治疗应用的探针或载体。通过将量子点与靶向配体偶联，可以将量子点功能化以靶向特定的细胞或组织。在制造生物相容的QD制剂方面的最新进展使这些纳米晶适合在体内应用。本文综述了量子点的制备及其作为探针或载体在体内外可追踪、靶向治疗疾病中的应用。更具体地说，重点介绍了量子点与用于治疗的药物配方的集成以及它们在体外和体内的潜在毒性方面的最新进展。描述了在最佳大小和稳定性、短期和长期毒性以及体内应用方面优化QD/药物配方的当前发现和挑战。最后，我们试图预测未来几年QD/药物制剂发展的主要趋势，并强调它们的使用可能在不久的将来提供突破性结果的治疗领域。
Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recent advancement in making biocompatible QD formulations has made these nanocrystals suitable for in vivo applications. This review provides an overview of the preparation of QDs and their use as probes or carriers for traceable, targeted therapy of diseases in vitro and in vivo. More specifically, recent advances in the integration of QDs with drug formulations for therapy and their potential toxicity in vitro and in vivo are highlighted. The current findings and challenges for optimizing QD/drug formulations with respect to optimal size and stability, short-term and long-term toxicity, and in vivo applications are described. Lastly, we attempt to predict key trends in QD/drug formulation development over the next few years and highlight areas of therapy where their use may provide breakthrough results in the near future.
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DOI：
10.1073/pnas.152463399
发表时间：
2002-10-01
影响因子：
11.1
作者：
Åkerman, ME;Chan, WCW;Ruoslahti, E
通讯作者：
Ruoslahti, E
影响因子：
4.6
作者：
Adeli, Mohsen;Hakimpoor, Farahman;Attyabi, Fatemeh
通讯作者：
Attyabi, Fatemeh
影响因子：
15
作者：
Bharali, DJ;Lucey, DW;Prasad, PN
通讯作者：
Prasad, PN
影响因子：
3.6
作者：
Dong, Wei;Guo, Li;Xu, Shukun
通讯作者：
Xu, Shukun
影响因子：
14
作者：
Cheng, Jianjun;Teply, Benjamin A.;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.