Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study.
Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study.
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DOI：
10.1186/ar3223
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发表时间：
2011-01-17
影响因子：
4.9
通讯作者：
Gutiérrez M
中科院分区：
文献类型：
--
作者：
Pineda C;Amezcua-Guerra LM;Solano C;Rodriguez-Henríquez P;Hernández-Díaz C;Vargas A;Hofmann F;Gutiérrez M
在这项研究中，我们的目的是调查超声（US）的变化，提示痛风性关节炎的透明软骨，关节和肌腱的无症状个体高尿酸血症。我们进行了一项横断面对照研究，包括膝关节和第一跖趾关节（第一MTPJ）以及下肢肌腱和附着点的US检查。通过χ2或非配对t检验（如适用）估计差异。使用斯皮尔曼相关系数秩检验计算关联性。50例无症状高尿酸血症患者和52例正常尿酸血症受试者入选。高尿酸血症患者中25%的首次MTPJ可见透明软骨浅缘高回声增强（双轮廓征），而对照组中无此现象（P < 0.0001）。在股骨软骨上也发现了类似的结果（17%对0; P < 0.0001）。髌骨末端病变（12%对2.9%; P = 0.01）和痛风石（6%对0; P = 0.01）以及跟腱末端病变（15%对1.9%; P = 0.0007）在高尿酸血症患者中比在正常尿酸血症患者中更常见。关节内痛风石被发现在8个高尿酸血症的个人，但在正常尿酸血症的主题（P = 0.003）。这些数据表明，慢性高尿酸血症诱发的痛风性关节炎的形态结构变化经常发生在临床无症状个体的关节内和关节外结构中。
In this study, we aimed to investigate ultrasonographic (US) changes suggestive of gouty arthritis in the hyaline cartilage, joints and tendons from asymptomatic individuals with hyperuricemia. We conducted a cross-sectional, controlled study including US examinations of the knees and first metatarsal-phalangeal joints (first MTPJs), as well as of the tendons and enthesis of the lower limbs. Differences were estimated by χ2 or unpaired t-tests as appropriate. Associations were calculated using the Spearman's correlation coefficient rank test. Fifty asymptomatic individuals with hyperuricemia and 52 normouricemic subjects were included. Hyperechoic enhancement of the superficial margin of the hyaline cartilage (double contour sign) was found in 25% of the first MTPJs from hyperuricemic individuals, in contrast to none in the control group (P < 0.0001). Similar results were found on the femoral cartilage (17% versus 0; P < 0.0001). Patellar enthesopathy (12% versus 2.9%; P = 0.01) and tophi (6% versus 0; P = 0.01) as well as Achilles enthesopathy (15% versus 1.9%; P = 0.0007) were more frequent in hyperuricemic than in normouricemic individuals. Intra-articular tophi were found in eight hyperuricemic individuals but in none of the normouricemic subjects (P = 0.003). These data demonstrate that morphostructural changes suggestive of gouty arthritis induced by chronic hyperuricemia frequently occur in both intra- and extra-articular structures of clinically asymptomatic individuals.
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影响因子：
16.2
作者：
Rodrigues, Ticiana C.;Maahs, David M.;Snell-Bergeon, Janet K.
通讯作者：
Snell-Bergeon, Janet K.
影响因子：
5.5
作者：
Thiele, R. G.;Schlesinger, N.
通讯作者：
Schlesinger, N.
DOI：
10.3899/jrheum.080646
发表时间：
2009-02
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Neogi T;Ellison RC;Hunt S;Terkeltaub R;Felson DT;Zhang Y
通讯作者：
Zhang Y
影响因子：
5.5
作者：
Haslam, Kirsty E.;McCann, Liza J.;Wakefield, Richard J.
通讯作者：
Wakefield, Richard J.
影响因子：
--
作者：
ROUAULT, T;CALDWELL, DS;HOLMES, EW
通讯作者：
HOLMES, EW