Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure.
Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure.
复制标题
使用具有互连多孔结构的碳酸盐磷灰石蜂窝块重建兔下颌骨缺损。
DOI：
10.1007/s10856-022-06710-2
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发表时间：
2022-12-31
影响因子：
3.7
通讯作者：
Miyamoto, Youji
中科院分区：
文献类型：
--
作者：
Kudoh, Keiko;Fukuda, Naoyuki;Akita, Kazuya;Kudoh, Takaharu;Takamaru, Natsumi;Kurio, Naito;Hayashi, Koichiro;Ishikawa, Kunio;Miyamoto, Youji
碳酸盐磷灰石 (CO3Ap) 颗粒可用作骨替代品，因为它们可以以符合骨重塑过程的方式重塑为新的天然骨。然而，由于其颗粒形状，使用 CO3Ap 颗粒重建大骨缺损很困难。因此，我们制造了具有连续单向孔的 CO3Ap 蜂窝块（HCB）。我们的目的是阐明 CO3Ap HCB 在下颌边缘切除术后重建兔下颌骨缺损中的组织反应和可用性。根据组织学图像估计剩余 CO3Ap 面积和钙化骨面积（新形成的骨）的百分比。 CO3Ap 面积分别为 49.1±±4.9%、30.3±3.5% 和 25.5±±8.8%，而新形成骨面积分别为 3.0±±0.6%、24.3±±3.3% 和 34.7±±4.8%分别为植入后 4、8 和 12 周。因此，CO3Ap HCB 逐渐被新骨吸收并取代。植入后 12 周，新形成的骨穿透了 CO3Ap HCB 的大部分孔。相比之下，肉芽组织几乎没有侵入CO3Ap HCB。一些破骨细胞侵入 CO3Ap HCB 壁，形成吸收凹坑。此外，在新形成的骨骼上发现了许多成骨细胞，表明骨骼重塑正在进行。 CO3Ap HCB 的大部分孔内也形成了血管。这些发现表明CO3Ap HCB具有良好的骨传导性，可用于大下颌骨缺损的重建。 CO3Ap HCB 逐渐被新形成的骨吸收并取代。
Carbonate apatite (CO3Ap) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using CO3Ap granules is difficult because of their granular shape. Therefore, we fabricated CO3Ap honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of CO3Ap HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining CO3Ap area and calcified bone area (newly formed bone) were estimated from the histological images. CO3Ap area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, CO3Ap HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the CO3Ap HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the CO3Ap HCBs. Some osteoclasts invaded the wall of CO3Ap HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the CO3Ap HCBs. These findings suggest that CO3Ap HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects. The CO3Ap HCB were gradually resorbed and replaced by newly formed bone.
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影响因子：
4.9
作者：
Frosch, KH;Barvencik, F;Stürmer, KM
通讯作者：
Stürmer, KM
影响因子：
14
作者：
Chang, BS;Lee, CK;Park, KW
通讯作者：
Park, KW
DOI：
10.3390/ma11101993
发表时间：
2018-10-16
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Ishikawa K;Miyamoto Y;Tsuchiya A;Hayashi K;Tsuru K;Ohe G
通讯作者：
Ohe G
影响因子：
1.1
作者：
Ishikawa, Kunio;Matsuya, Shigeki;Miyamoto, Youji
通讯作者：
Miyamoto, Youji
影响因子：
5.5
作者：
Ishikawa K;Hayashi K
通讯作者：
Hayashi K