Effect of reproductive status on hypothalamic-pituitary-adrenal (HPA) activity and reactivity in male California mice (Peromyscus californicus).
Effect of reproductive status on hypothalamic-pituitary-adrenal (HPA) activity and reactivity in male California mice (Peromyscus californicus).
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DOI：
10.1016/j.physbeh.2013.02.016
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发表时间：
2013-03-15
影响因子：
2.9
通讯作者：
Saltzman W
中科院分区：
文献类型：
--
作者：
Harris BN;Saltzman W
以往的研究表明，生殖条件可以改变应激反应和糖皮质激素的释放。虽然下丘脑-垂体-肾上腺（HPA）轴通过繁殖条件调节的功能意义尚未完全了解，但一个可能的解释是行为假说，该假说认为动物表达父母行为的需要可能是HPA轴的驱动调节。这种可能性与哺乳期雌性哺乳动物HPA轴的钝化活性和反应性的发现一致;然而，生殖状态对HPA功能的影响在表达亲本行为的雄性哺乳动物中尚未得到很好的表征。因此，我们在一夫一妻制和双亲加州小鼠中检验了这一假设。HPA活性的几个方面进行了比较，在男性从三个生殖条件：处女男性（与另一名男性），非繁殖男性（与输卵管结扎的女性），和第一次父亲（与女性和他们的第一窝幼崽）。根据行为假说，我们预测，新的父亲将不同于处女和非繁殖男性在几个方面的HPA功能和皮质酮（CORT）输出：减少振幅的昼夜节律的CORT，钝CORT增加捕食者气味压力，增加糖皮质激素负反馈的敏感性，和/或钝CORT响应药理刺激。此外，我们预测，第一次父亲将更耐皮质激素诱导的睾酮分泌抑制，因为睾酮是重要的父行为在这个物种。我们发现，处女男性，非繁殖男性和第一次父亲没有显示任何CORT的昼夜节律，反应捕食者气味应激，或响应药理抑制或刺激的差异。此外，循环睾酮浓度无差异。肾上腺质量，但是，显着低于新的父亲比处女或非繁殖男性。这些结果表明，行为假说不能解释HPA功能在雄性加州小鼠的生殖条件。
Previous studies indicate that reproductive condition can alter the stress response and glucocorticoid release. Although the functional significance of hypothalamic-pituitary-adrenal (HPA) axis modulation by breeding condition is not fully understood, one possible explanation is the behavior hypothesis, which states that an animal’s need to express parental behavior may be driving modulation of the HPA axis. This possibility is consistent with findings of blunted activity and reactivity of the HPA axis in lactating female mammals; however, effects of reproductive status on HPA function have not been well characterized in male mammals that express parental behavior. Therefore, we tested this hypothesis in the monogamous and biparental California mouse. Several aspects of HPA activity were compared in males from three reproductive conditions: virgin males (housed with another male), non-breeding males (housed with a tubally ligated female), and first-time fathers (housed with a female and their first litter of pups). In light of the behavior hypothesis we predicted that new fathers would differ from virgin and non-breeding males in several aspects of HPA function and corticosterone (CORT) output: decreased amplitude of the diurnal rhythm in CORT, a blunted CORT increase following predator-odor stress, increased sensitivity to glucocorticoid negative feedback, and/or a blunted CORT response to pharmacological stimulation. In addition, we predicted that first-time fathers would be more resistant to CORT-induced suppression of testosterone secretion, as testosterone is important for paternal behavior in this species. We found that virgin males, non-breeding males and first-time fathers did not display any CORT differences in diurnal rhythm, response to a predator-odor stressor, or response to pharmacological suppression or stimulation. Additionally, there were no differences in circulating testosterone concentrations. Adrenal mass was, however, significantly lower in new fathers than in virgin or non-breeding males. These results suggest that the behavior hypothesis does not explain HPA function across reproductive conditions in male California mice.
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影响因子：
3.5
作者：
de Jong, Trynke R.;Chauke, Miyetani;Saltzman, Wendy
通讯作者：
Saltzman, Wendy
影响因子：
2.5
作者：
Cantoni, D;Brown, RE
通讯作者：
Brown, RE
影响因子：
3.5
作者：
Chauke, Miyetani;Malisch, Jessica L.;Robinson, Cymphonee;de Jong, Trynke R.;Saltzman, Wendy
通讯作者：
Saltzman, Wendy
DOI：
10.1038/npp.2008.154
发表时间：
2009-05
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
1.6
作者：
de Jong, Trynke R.;Korosi, Aniko;Saltzman, Wendy
通讯作者：
Saltzman, Wendy