Effects of reproductive status on behavioral and endocrine responses to acute stress in a biparental rodent, the California mouse (Peromyscus californicus).
Effects of reproductive status on behavioral and endocrine responses to acute stress in a biparental rodent, the California mouse (Peromyscus californicus).
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DOI：
10.1016/j.yhbeh.2011.04.002
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发表时间：
2011-06
影响因子：
3.5
通讯作者：
Saltzman, Wendy
中科院分区：
文献类型：
--
作者：
Chauke, Miyetani;Malisch, Jessica L.;Robinson, Cymphonee;de Jong, Trynke R.;Saltzman, Wendy
在一些哺乳动物物种中，哺乳期雌性动物对压力源表现出迟钝的神经，激素和行为反应。目前尚不清楚，在由雄性提供婴儿护理的物种中，新父亲是否也表现出应激低反应。为了验证这种可能性，我们确定了雄性和雌性生殖状态对双亲、一夫一妻制加州小鼠应激反应的影响（Peromyscus californicus）.育种（N=8只雌性，8只雄性），非育种（N=10只雌性，10只雄性）和未交配小鼠（N=12只雌性，9只雄性）在两个时间点暴露于5分钟的捕食者-尿应激物，对应于产后早期（产后5-7天）和产后中期/晚期（产后19-21天）阶段，并且随后立即收集血液样品。在每次强制降解试验前2天采集基线血样。基线血浆皮质酮（CORT）浓度在男性或女性组之间没有差异。CORT反应的压力没有不同的女性生殖组，和所有三个组表现出不同的行为反应捕食者尿。处女男性倾向于增加他们的CORT反应从第一次到第二次压力测试，而繁殖和nonbreeding男性没有。此外，处女和nonbreeding男性表现出显着的行为变化，在回应捕食者尿液，而繁殖男性没有。这些结果表明，在雄性加州小鼠的肾上腺皮质反应的重复应激可能是调制同居与女性，而行为反应的压力可能是钝化的父母的地位。
In several mammalian species, lactating females show blunted neural, hormonal, and behavioral responses to stressors. It is not known whether new fathers also show stress hyporesponsiveness in species in which males provide infant care. To test this possibility, we determined the effects of male and female reproductive status on stress responsiveness in the biparental, monogamous California mouse (Peromyscus californicus).Breeding (N=8 females, 8 males), nonbreeding (N=10 females, 10 males) and virgin mice (N=12 females, 9 males) were exposed to a 5-min predator-urine stressor at two time points, corresponding to the early postpartum (5–7 days postpartum) and mid/late postpartum (19–21 days postpartum) phases, and blood samples were collected immediately afterwards. Baseline blood samples were obtained 2 days prior to each stress test. Baseline plasma corticosterone (CORT) concentrations did not differ among male or female groups. CORT responses to the stressor did not differ among female reproductive groups, and all three groups showed distinct behavioral responses to predator urine. Virgin males tended to increase their CORT response from the first to the second stress test, while breeding and nonbreeding males did not. Moreover, virgin and nonbreeding males showed significant behavioral changes in response to predator urine, whereas breeding males did not. These results suggest that adrenocortical responses to a repeated stressor in male California mice may be modulated by cohabitation with a female, whereas behavioral responses to stress may be blunted by parental status.
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影响因子：
2.7
作者：
Fedriani, JM;Fuller, TK;York, EC
通讯作者：
York, EC
影响因子：
3.5
作者：
de Jong, Trynke R.;Chauke, Miyetani;Saltzman, Wendy
通讯作者：
Saltzman, Wendy
DOI：
10.1016/s0169-328x(01)00137-1
发表时间：
2001-07-13
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
da Costa, APC;Ma, XM;Aguilera, G
通讯作者：
Aguilera, G
影响因子：
3.7
作者：
Detillion, CE;Craft, TKS;DeVries, AC
通讯作者：
DeVries, AC
影响因子：
3.3
作者：
Casolini, P;Cigliana, G;Catalani, A
通讯作者：
Catalani, A