The Cutaneous Wound Innate Immunological Microenvironment.
The Cutaneous Wound Innate Immunological Microenvironment.
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DOI：
10.3390/ijms21228748
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发表时间：
2020-11-19
影响因子：
5.6
通讯作者：
MacLeod AS
中科院分区：
文献类型：
--
作者：
Kirchner S;Lei V;MacLeod AS
皮肤是抵御病原体的第一道防线和先天免疫保护。皮肤通常提供一种物理屏障，防止病原体感染；然而，伤口、微损伤以及轻微的屏障障碍可能为病原体通过皮肤入侵提供途径。因此，伤口修复以及防止病原体入侵是皮肤屏障成功再生的关键过程。为了修复和保护伤口，皮肤会促进在受损组织内部及其周围形成一种特定且复杂的免疫微环境。这种免疫微环境包括先天和适应性过程，包括免疫细胞向伤口募集以及细胞外因子的分泌，这些因子可直接促进伤口闭合和伤口的抗菌防御。近期的研究表明，这种免疫微环境也会根据伤口的具体情况而有所不同：微生物组、神经免疫信号传导、环境影响以及年龄在改变对创伤的先天免疫反应中都起作用。这篇综述将重点关注这些因素在塑造皮肤微环境中的作用，以及这最终如何影响对创伤的免疫反应。
The skin represents the first line of defense and innate immune protection against pathogens. Skin normally provides a physical barrier to prevent infection by pathogens; however, wounds, microinjuries, and minor barrier impediments can present open avenues for invasion through the skin. Accordingly, wound repair and protection from invading pathogens are essential processes in successful skin barrier regeneration. To repair and protect wounds, skin promotes the development of a specific and complex immunological microenvironment within and surrounding the disrupted tissue. This immune microenvironment includes both innate and adaptive processes, including immune cell recruitment to the wound and secretion of extracellular factors that can act directly to promote wound closure and wound antimicrobial defense. Recent work has shown that this immune microenvironment also varies according to the specific context of the wound: the microbiome, neuroimmune signaling, environmental effects, and age play roles in altering the innate immune response to wounding. This review will focus on the role of these factors in shaping the cutaneous microenvironment and how this ultimately impacts the immune response to wounding.
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DOI：
10.4049/jimmunol.1201213
发表时间：
2013-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brubaker AL;Rendon JL;Ramirez L;Choudhry MA;Kovacs EJ
通讯作者：
Kovacs EJ
影响因子：
2.7
作者：
Gardiner M;Vicaretti M;Sparks J;Bansal S;Bush S;Liu M;Darling A;Harry E;Burke CM
通讯作者：
Burke CM
影响因子：
3.4
作者：
Bos S;Gadea G;Despres P
通讯作者：
Despres P
影响因子：
4.9
作者：
Dai, Tianhong;Garcia, Barbara;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
7.3
作者：
Deckers J;Hammad H;Hoste E
通讯作者：
Hoste E