The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008.
The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008.
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DOI：
10.1371/journal.pone.0025662
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Xu W
中科院分区：
文献类型：
--
作者：
Tan X;Huang X;Zhu S;Chen H;Yu Q;Wang H;Huo X;Zhou J;Wu Y;Yan D;Zhang Y;Wang D;Cui A;An H;Xu W
与肠道病毒71型（EV 71）相关的手足口病（HFMD）新流行已成为中国大陆的一个严重问题。2008年和2009年分别造成126人和353人死亡。从国家实验室网络和法定报告疾病监测系统收集的疫情流行病学和病原学数据。为了了解此次暴发的病毒学演变，收集了1987 - 2009年在中国发现的326个EV 71的VP 1基因序列进行遗传分析。传统流行病学和分子流行病学证据均证实，此次手足口病暴发是由EV 71 C4亚型引起的新发疫情。这次新出现的手足口病暴发与1998年以来在中国大陆持续流行的EV 71亚型C4基因型有关，但与新基因型的输入无关。C4亚型起源于1992年，自1998年以来一直是中国大陆的优势基因型，进化速率为4.6 × 4.8×10−3个核苷酸替换/位点/年。系统发育分析表明，在这次流行中的大多数病毒是C4亚型（C4 a分支）的最新后代。这表明，这种进化可能是这种本土病毒在中国引起暴发的潜在原因之一。然而，对EV 71 VP 1蛋白的强负选择性压力表明，免疫逃逸可能不是EV 71的进化策略，预示着疫苗开发的光明前景。尽管如此，长期的抗原和遗传监测仍然是必要的，以进一步了解。
Emerging epidemics of hand-foot-and-mouth disease (HFMD) associated with enterovirus 71 (EV71) has become a serious concern in mainland China. It caused 126 and 353 fatalities in 2008 and 2009, respectively. The epidemiologic and pathogenic data of the outbreak collected from national laboratory network and notifiable disease surveillance system. To understand the virological evolution of this emerging outbreak, 326 VP1 gene sequences of EV71 detected in China from 1987 to 2009 were collected for genetic analyses. Evidence from both traditional and molecular epidemiology confirmed that the recent HFMD outbreak was an emerging one caused by EV71 of subgenotype C4. This emerging HFMD outbreak is associated with EV71 of subgenotype C4, circulating persistently in mainland China since 1998, but not attributed to the importation of new genotype. Originating from 1992, subgenotype C4 has been the predominant genotype since 1998 in mainland China, with an evolutionary rate of 4.6∼4.8×10−3 nucleotide substitutions/site/year. The phylogenetic analysis revealed that the majority of the virus during this epidemic was the most recent descendant of subgenotype C4 (clade C4a). It suggests that the evolution might be one of the potential reasons for this native virus to cause the emerging outbreak in China. However, strong negative selective pressure on VP1 protein of EV71 suggested that immune escape might not be the evolving strategy of EV71, predicting a light future for vaccine development. Nonetheless, long-term antigenic and genetic surveillance is still necessary for further understanding.
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影响因子：
4.6
作者：
MELNICK, JL;SCHMIDT, NJ;VOROSHILOVA, MK
通讯作者：
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DOI：
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发表时间：
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作者：
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作者：
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