Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol levels and coronary heart disease: results from the Framingham Offspring Study.
Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol levels and coronary heart disease: results from the Framingham Offspring Study.
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DOI：
10.1016/j.atherosclerosis.2010.02.041
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发表时间：
2010-11
期刊：
影响因子：
5.3
通讯作者：
Schaefer EJ
中科院分区：
文献类型：
--
作者：
Otokozawa S;Ai M;Asztalos BF;White CC;Demissie-Banjaw S;Cupples LA;Nakajima K;Wilson PW;Schaefer EJ
我们评估了直接低密度脂蛋白（LDL）胆固醇(C)和高密度脂蛋白（HDL）胆固醇(C)与标准方法相比，使用Framingham后代研究第6周期参与者的空腹血浆样本。对男性（1335名对照，173名冠心病患者）和女性（1606名对照，74名患者）的空腹血浆进行直接LDL-C和HDL-C测量，并与用Friedewald公式计算的LDL-C和用右旋糖酐- mg2 +沉淀后测量的HDL-C进行比较。直接LDL-C和HDL-C值与标准方法相关性良好（r2=0.94, p<0.001），绝对值相似。7.7%的LDL-C样本存在bb10 %的偏差，而HDL-C的偏差值为8.5%。尽管冠心病患者使用了较多的降胆固醇药物，但冠心病患者（尤其是女性）的计算或直接LDL-C值仍远高于推荐值[< 2.6 mmol/L, (100 mg/dl)]。LDL-C和HDL-C的直接测定为脂质治疗提供了可接受的指导。在弗雷明汉后代研究的参与者中，大多数冠心病患者的LDL-C水平高于推荐目标。
We evaluated direct low density lipoprotein (LDL) cholesterol (C) and high density lipoprotein (HDL) cholesterol (C) versus standard methods using fasting plasma samples from participants in cycle 6 of the Framingham Offspring Study. Direct LDL-C and HDL-C measurements were performed on fasting plasma from male (1335 controls, 173 CHD cases) and female (1606 controls, 74 cases) participants, and compared with LDL-C, as calculated with the Friedewald formula, and HDL-C, as measured after dextran-Mg2+ precipitation. Values for direct LDL-C and HDL-C correlated well with standard methods (both about r2=0.94, p<0.001) with similar absolute values. Biases of > 10% were present for 7.7% of samples for LDL-C, while for HDL-C this value was 8.5%. Despite higher use of cholesterol lowering medication in CHD cases, calculated or direct LDL-C values were still well above recommended values [< 2.6 mmol/L, (100 mg/dl)] in CHD cases, especially in females. Direct assays for both LDL-C and HDL-C provide an acceptable guide for lipid treatment. In the Framingham Offspring Study participants, most CHD cases have LDL-C levels above the recommended target.
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影响因子：
120.7
作者：
Ingelsson, Erik;Schaefer, Ernst J.;Vasan, Ramachandran S.
通讯作者：
Vasan, Ramachandran S.
影响因子：
2.8
作者：
Kurosawa, Hideo;Yoshida, Hiroshi;Tada, Norio
通讯作者：
Tada, Norio
影响因子：
5
作者：
Tsai, LY;Tsai, SM;Liu, SF
通讯作者：
Liu, SF
DOI：
10.1177/107424840501000106
发表时间：
2005-03-01
影响因子：
2.6
作者：
Bairaktari, ET;Seferiadis, KI;Elisaf, MS
通讯作者：
Elisaf, MS
影响因子：
1.6
作者：
de Ferranti, Sarah;Shapiro, David;Bernstein, Henry
通讯作者：
Bernstein, Henry