In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials.
In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials.
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DOI：
10.1126/sciadv.aao1175
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发表时间：
2018-01
期刊：
影响因子：
13.6
通讯作者：
Karperien M
中科院分区：
文献类型：
--
作者：
Visser CW;Kamperman T;Karbaat LP;Lohse D;Karperien M
Designer microparticles and multiscale materials can be fabricated in one step by microfluidic processing in the air. Microfluidic chips provide unparalleled control over droplets and jets, which have advanced all natural sciences. However, microfluidic applications could be vastly expanded by increasing the per-channel throughput and directly exploiting the output of chips for rapid additive manufacturing. We unlock these features with in-air microfluidics, a new chip-free platform to manipulate microscale liquid streams in the air. By controlling the composition and in-air impact of liquid microjets by surface tension–driven encapsulation, we fabricate monodisperse emulsions, particles, and fibers with diameters of 20 to 300 μm at rates that are 10 to 100 times higher than chip-based droplet microfluidics. Furthermore, in-air microfluidics uniquely enables module-based production of three-dimensional (3D) multiscale (bio)materials in one step because droplets are partially solidified in-flight and can immediately be printed onto a substrate. In-air microfluidics is cytocompatible, as demonstrated by additive manufacturing of 3D modular constructs with tailored microenvironments for multiple cell types. Its in-line control, high throughput and resolution, and cytocompatibility make in-air microfluidics a versatile platform technology for science, industry, and health care.
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DOI：
10.1038/nrm4041
发表时间：
2015-09
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Duncombe TA;Tentori AM;Herr AE
通讯作者：
Herr AE
影响因子：
13.6
作者：
Hinton TJ;Jallerat Q;Palchesko RN;Park JH;Grodzicki MS;Shue HJ;Ramadan MH;Hudson AR;Feinberg AW
通讯作者：
Feinberg AW
影响因子：
9.5
作者：
Femmer, Tim;Jans, Alexander;Kuehne, Alexander J. C.
通讯作者：
Kuehne, Alexander J. C.
影响因子：
--
作者：
Both, Sanne K.;Van der Muijsenberg, Adrie J. C.;De Bruijn, Joost D.
通讯作者：
De Bruijn, Joost D.
影响因子：
4.6
作者：
Hendriks J;Willem Visser C;Henke S;Leijten J;Saris DB;Sun C;Lohse D;Karperien M
通讯作者：
Karperien M