Clinical implications of bone marrow adiposity.
Clinical implications of bone marrow adiposity.
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DOI：
10.1111/joim.12718
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发表时间：
2018-03
影响因子：
11.1
通讯作者：
Rosen CJ
中科院分区：
文献类型：
--
作者：
Veldhuis-Vlug AG;Rosen CJ
骨髓脂肪细胞，统称为骨髓脂肪组织（MAT），位于骨髓中，与骨细胞和造血细胞密切接触。骨髓脂肪细胞起源于间充质干细胞，并与成骨细胞共享其起源。间充质基质细胞谱系分配的变化可能解释MAT增加与绝经后骨质疏松症、神经性厌食症和糖尿病等疾病中骨折风险增加之间的关联。在功能上，骨髓脂肪细胞分泌脂肪因子，如脂联素，和细胞因子，如RANK-配体和干细胞因子。这些介质可以通过促进化疗后的骨吸收和造血恢复来影响骨重建和造血。此外，骨髓脂肪细胞可以分泌游离脂肪酸，作为骨骼和造血细胞的能量供应。然而，这种诱导的脂解也被肿瘤细胞用于促进存活和增殖。因此，MAT可能代表从骨质疏松症到白血病的多种疾病的新治疗靶点，尽管骨髓脂肪细胞在健康和疾病中的确切特性和作用仍有待确定。
Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone marrow in close contact to bone cells and hematopoietic cells. Marrow adipocytes arise from the mesenchymal stem cell and share their origin with the osteoblastst. Shifts in the lineage allocation of the mesenchymal stromal cell could potentially explain the association between increased MAT and increased fracture risk in diseases such as postmenopausal osteoporosis, anorexia nervosa and diabetes. Functionally, marrow adipocytes secrete adipokines, such as adiponectin, and cytokines, such as RANK-ligand and stem cell factor. These mediators can influence both bone remodeling and hematopoiesis by promoting bone resorption and hematopoietic recovery following chemotherapy. In addition, marrow adipocytes can secrete free fatty acids, acting as a energy supply for bone and hematopoietic cells. However, this induced lipolysis is also used by neoplastic cells to promote survival and proliferation. Therefore, MAT could represent a new therapeutic target for multiple diseases from osteoporosis to leukemia, although the exaxt characteristics and role of the marrow adipocyte in health and diseases remains to be determined.
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影响因子：
3.7
作者：
Adler BJ;Green DE;Pagnotti GM;Chan ME;Rubin CT
通讯作者：
Rubin CT
影响因子：
4.1
作者：
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通讯作者：
Affuso O
DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
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通讯作者：
Miller KK
影响因子：
4.1
作者：
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通讯作者：
Miller, Karen K.
影响因子：
4.4
作者：
Cordes, Christian;Dieckmeyer, Michael;Karampinos, Dimitrios C.
通讯作者：
Karampinos, Dimitrios C.