Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord.
Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord.
复制标题
斑马鱼脊髓发育过程中运动前抑制的有序区块定位。
DOI：
10.1126/science.abb4608
复制
发表时间：
2020-10-23
期刊：
影响因子：
--
通讯作者：
McLean DL
中科院分区：
文献类型：
--
作者：
Kishore S;Cadoff EB;Agha MA;McLean DL
在脊椎动物中，增加速度的运动涉及不同类型的脊髓运动神经元的有序募集。然而，目前还不知道如何组织前运动抑制电路，以确保交替模式的拮抗运动输出在不同的速度。在这里，我们发现，不同类型的连合抑制性中间神经元在斑马鱼形成房室微电路在发展过程中，对齐的潜力，相互抑制招聘秩序。轴突微电路首先发展，并在最快的运动过程中提供对拮抗运动神经元的最有效的抑制，其次是体周微电路，然后是在最慢的运动过程中提供最弱抑制的树突微电路。这种模式桥接运动神经元类型，尽管更快、更早出生的运动神经元表现出更强的体周神经支配。将神经元发育的时间序列转换成相互抑制连接的空间模式提供了一种“个体发育”的解决方案，以不同的运动速度塑造脊髓运动输出的问题。发育中的脊髓抑制性中间神经元形成隔室微电路，以确保以后生活中适当的运动输出模式。
In vertebrates, movements of increasing speed involve the orderly recruitment of different types of spinal motor neurons. However, it is not known how premotor inhibitory circuits are organized to ensure alternating patterns of antagonistic motor output at different speeds. Here, we find that distinct types of commissural inhibitory interneurons in zebrafish form compartmental microcircuits during development that align the potency of reciprocal inhibition with recruitment order. Axonal microcircuits develop first and provide the most potent inhibition of antagonistic motor neurons during the fastest movements, followed by perisomatic microcircuits, and then dendritic microcircuits that provide the weakest inhibition during the slowest movements. This pattern bridges motor neuron types, although faster, earlier-born motor neurons exhibit stronger perisomatic innervation. The conversion of a temporal sequence of neuronal development into a spatial pattern of reciprocal inhibitory connections provides an ‘ontogenotopic’ solution to the problem of shaping spinal motor output at different speeds of movement. Developing spinal inhibitory interneurons form compartmental microcircuits that ensure appropriate patterns of motor output later on in life.
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