Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment.
Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment.
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DOI：
10.3389/fnagi.2017.00264
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发表时间：
2017
影响因子：
4.8
通讯作者：
Ewers M
中科院分区：
文献类型：
--
作者：
Franzmeier N;Göttler J;Grimmer T;Drzezga A;Áraque-Caballero MA;Simon-Vermot L;Taylor ANW;Bürger K;Catak C;Janowitz D;Müller C;Duering M;Sorg C;Ewers M
储备是指与神经病理程度不成比例的相对保存的认知现象，如阿尔茨海默病。左侧额外侧皮质（LFC, Brodmann Area 6/44）的全球功能连通性被认为是潜在的功能性神经基质。在轻度认知障碍（MCI）中，静息状态fmri评估的全球lfc连接与保护因素（教育）和更好的记忆维持有关。由于LFC是额顶叶控制网络的中枢，而额顶叶控制网络调节其他网络的活动，因此问题就出现了，LFC与特定网络的连接，而不是整个大脑的连接，是否可能是储备的基础。我们评估了24名MCI和16名健康对照（HC）以及独立验证样本（23名MCI/32名HC）的静息状态fMRI。计算基于种子的lfc与七个主要静息状态网络（即额顶叶、边缘、背侧注意、体运动、默认模式、腹侧注意、视觉）的连通性，并在考虑年龄和海马萎缩后将储备量化为剩余记忆表现。在两个MCI样本中，lfc活性与默认模式网络（DMN）呈反相关，而与背侧注意网络（DAN）呈正相关。教育程度越高，lfc - dmn -连通性（反相关）和lfc - dan -连通性越强。更强的LFC-DMN和lfc - dan -连通性各自预测更高的储备，在两个MCI样本中一致。没有检测到lfc连接到其他网络的关联。这些新结果扩展了我们之前关于LFC整体功能连通性的发现，表明LFC与DAN和DMN这两个核心记忆网络的连通性增强了MCI记忆域的储备。
Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer’s disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.
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DOI：
10.3233/jad-170360
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Franzmeier N;Hartmann JC;Taylor ANW;Araque Caballero MÁ;Simon-Vermot L;Buerger K;Kambeitz-Ilankovic LM;Ertl-Wagner B;Mueller C;Catak C;Janowitz D;Stahl R;Dichgans M;Duering M;Ewers M
通讯作者：
Ewers M
影响因子：
9.9
作者：
Ewers, Michael;Insel, Philip S.;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
影响因子：
3.7
作者：
Koch, Kathrin;Myers, Nicholas E.;Sorg, Christian
通讯作者：
Sorg, Christian
DOI：
10.1177/1073858414525995
发表时间：
2014-12
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Cole MW;Repovš G;Anticevic A
通讯作者：
Anticevic A