Study of the Impact of Uterine Artery Embolization (UAE) on Endometrial Microvessel Density (MVD) and Angiogenesis
Study of the Impact of Uterine Artery Embolization (UAE) on Endometrial Microvessel Density (MVD) and Angiogenesis
复制标题
子宫动脉栓塞术 (UAE) 对子宫内膜微血管密度 (MVD) 和血管生成影响的研究
DOI：
10.1007/s00270-013-0599-x
复制
发表时间：
2013-03
影响因子：
2.9
通讯作者：
Yang, Jianyong
中科院分区：
文献类型：
--
作者：
Guo, Wenbo;Zhang, Bing;Chen, Wei;Yang, Jianyong
目的探讨子宫动脉栓塞术（UAE）对子宫内膜微血管密度（MVD）及血管生成的影响。UAE组采用三丙烯酰明胶微球栓塞。将动物进一步分为三个亚组，A1、A2和A3（每个亚组n= 15），分别在UAE后7-15、16-30和31-45天采集子宫标本。采用免疫组化法检测子宫内膜总MVD（MVDFVIII）和CD 105阳性血管生成结果定量分析显示，A1区MVDFVIII显著降低，A2区MVDFVIII显著降低，A3区MVDFVIII显著降低，A1区MVDFVIII显著降低，A3区MVDFVIII显著降低，A4区MVD A2组（11.40 ± 2.76，p < 0.05）和A2组（15.37 ± 3.06，p < 0.05）与对照组（19.40 ± 2.50）比较，A3组（18.77 ± 2.69）恢复正常。UAE导致A1组中MVDCD 105阳性血管生成暂时上调（9.33 ± 2.37，p < 0.05）与A2组比较（11.63 ± 1.56，p < 0.05）与对照组比较（7.12 ± 1.67），A3组MVDCD 105恢复正常（8.07 ± 1.97）。结论UAE可引起子宫内膜MVD暂时性降低，但随着时间的推移，MVD逐渐逆转，这可能与CD 105阳性血管生成增加有关。UAE引起的子宫内膜微血管密度降低是可逆的，但其对子宫内膜容受性的长期影响仍需进一步研究。
PurposeTo investigate the influence of uterine artery embolization (UAE) on endometrial microvessel density (MVD) and angiogenesis.MethodsSixty female guinea pigs were divided into two groups, the control group (n= 15) and the UAE treatment group (n= 45). In the UAE group, tris–acryl gelatin microspheres were used to generate embolization. Animals were further divided into three subgroups, A1, A2, and A3 (n= 15 for each subgroup), with uterine specimens collected at 7–15, 16–30, and 31–45 days after UAE, respectively. Immunostaining for factor VIII and CD105 was performed to identify total endometrial MVD (MVDFVIII) and CD105-positive angiogenesis (MVDCD105) at the indicated time points after UAE.ResultsQuantitative analysis revealed that MVDFVIIIsignificantly decreased in the A1 (11.40 ± 2.76,p< 0.05) and A2 (15.37 ± 3.06,p< 0.05) groups compared to the control group (19.40 ± 2.50), and was restored to normal in the A3 group (18.77 ± 2.69). UAE caused a temporal up-regulation of MVDCD105-positive angiogenesis in the A1 group (9.33 ± 2.37,p< 0.05) and the A2 group (11.63 ± 1.56,p< 0.05) compared to the control group (7.12 ± 1.67), and the MVDCD105value returned to normal in the A3 group (8.07 ± 1.97).ConclusionUAE caused a temporal decrease in endometrial MVD that reversed over time as a result of the increase of CD105-positive angiogenesis. Although the UAE-induced reduction of endometrial MVD was reversible, its long-term effect on endometrial receptivity still needs further study.
登录
查看更多内容
影响因子：
0.4
作者：
B. B. da Silva-B.;P. V. Lopes-Costa;A. R. Dos Santos;E. C. de Sousa-Júnior;A. Alencar;C. G. Pires;M. Rosal
通讯作者：
B. B. da Silva-B.;P. V. Lopes-Costa;A. R. Dos Santos;E. C. de Sousa-Júnior;A. Alencar;C. G. Pires;M. Rosal
影响因子：
2.9
作者：
Wenquan Zhuang;Guosheng Tan;Wenbo Guo;Jian-yong Yang
通讯作者：
Wenquan Zhuang;Guosheng Tan;Wenbo Guo;Jian-yong Yang
DOI：
10.1530/jrf.0.1170153
发表时间：
1999-09-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
Naderali, EK;Wray, S
通讯作者：
Wray, S
DOI：
--
发表时间：
1995-07
期刊：
The American journal of pathology
影响因子：
--
作者：
N. Weidner
通讯作者：
N. Weidner
评估小鼠的生殖状态/阶段。
影响因子：
--
作者：
Caligioni, Claudia S
通讯作者：
Caligioni, Claudia S