Metabotropic glutamate receptors: from the workbench to the bedside.
Metabotropic glutamate receptors: from the workbench to the bedside.
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DOI：
10.1016/j.neuropharm.2010.10.022
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发表时间：
2011-06
影响因子：
4.7
通讯作者：
Pin, J. P.
中科院分区：
文献类型：
--
作者：
Nicoletti, E.;Bockaert, J.;Collingridge, G. L.;Conn, P. J.;Ferraguti, F.;Schoepp, D. D.;Wroblewski, J. T.;Pin, J. P.
代谢性谷氨酸(MGlu)受体是在20世纪80年代中期发现的，最初被描述为与多聚磷肌醇水解物偶联的谷氨酸受体。自那时以来，已发表了近6,500篇文章，亚型选择性mGlu受体配体目前正在临床开发中，用于治疗多种疾病，如脆性X综合征、精神分裂症、帕金森病和L-多巴诱导的运动障碍、广泛性焦虑障碍、慢性疼痛和胃食道反流障碍。埃尔米尼奥·科斯塔教授被认为与mGlu受体历史的早期有关，当时几个研究小组挑战了人们的普遍看法，即谷氨酸只能激活离子受体，对谷氨酸的所有代谢反应都是次要的钙离子进入。这篇综述从那些怀旧的时代转移到mGlu受体的生理学和药理学的最新进展，并强调了单个mGlu受体亚型在人类疾病的病理生理学中的作用。本文是题为《神经药理学趋势：纪念埃尔米尼奥·科斯塔》的特刊的一部分。
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective mGlu receptor ligands are now under clinical development for the treatment of a variety of disorders such as Fragile-X syndrome, schizophrenia, Parkinson’s disease and L-DOPA-induced dyskinesias, generalized anxiety disorder, chronic pain, and gastroesophageal reflux disorder. Prof. Erminio Costa was linked to the early times of the mGlu receptor history, when a few research groups challenged the general belief that glutamate could only activate ionotropic receptors and all metabolic responses to glutamate were secondary to calcium entry. This review moves from those nostalgic times to the most recent advances in the physiology and pharmacology of mGlu receptors, and highlights the role of individual mGlu receptor subtypes in the pathophysiology of human disorders. This article is part of a Special Issue entitled ‘Trends in Neuropharmacology: In Memory of Erminio Costa’.
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影响因子：
5.3
作者：
Ansah, Osei B.;Goncalves, Leonor;Pertovaara, Antti
通讯作者：
Pertovaara, Antti
影响因子：
2.5
作者：
Battaglia, G;Monn, JA;Schoepp, DD
通讯作者：
Schoepp, DD
影响因子：
5.6
作者：
Aronica, E;Gorter, JA;Troost, D
通讯作者：
Troost, D
影响因子：
64.5
作者：
AIBA, A;CHEN, C;TONEGAWA, S
通讯作者：
TONEGAWA, S
影响因子：
2.7
作者：
Ansah, Osei B.;Bourbia, Nora;Pertovaara, Antti
通讯作者：
Pertovaara, Antti