Brain temperature homeostasis: physiological fluctuations and pathological shifts.
Brain temperature homeostasis: physiological fluctuations and pathological shifts.
复制标题
大脑温度稳态：生理波动和病理转移。
DOI：
10.2741/3608
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Kiyatkin EA
中科院分区：
文献类型：
--
作者：
Kiyatkin EA
本工作的目的是讨论脑温度作为一个生理参数，它反映了代谢相关的脑内产热和脑循环到身体其他部位然后到外部环境的热损失之间的平衡。首先，我们提出了在生理和行为条件下发生的脑温度波动的数据，并讨论其机制。由于大多数控制神经活动的过程是温度依赖性的，我们考虑自然发生的温度波动如何影响神经活动和神经功能。然后，我们回顾了精神运动兴奋剂引起的大脑温度变化，并表明这些药物的过热效应是状态依赖性的，并受环境条件的调节。由于高温可能会不可逆地损害神经细胞，并显着恶化各种病理过程，我们认为与病理性脑高热的情况，并评估其在脑功能，神经毒性和神经变性的急性扰动的作用。我们还讨论了在生理调节和稳态的框架内考虑大脑温度的复杂性和局限性。虽然不同的适应机制可以在一定限度内补偿大脑的热平衡改变，但真实的生活往往会造成这种平衡无法补偿的情况，从而导致病理学和危及生命的健康并发症。
The goal of this work is to discuss brain temperature as a physiological parameter, which reflects the balance between metabolism-related intra-brain heat production and heat loss by cerebral circulation to the rest of the body and then to the external environment. First, we present data on fluctuations in brain temperature occurring under physiological and behavioral conditions and discuss their mechanisms. Since most processes governing neural activity are temperature-dependent, we consider how naturally occurring temperature fluctuations could affect neural activity and neural functions. Then, we review brain temperature changes induced by psychomotor stimulants and show that the hyperthermic effects of these drugs are state-dependent and modulated by environmental conditions. Since high temperature could irreversibly damage neural cells and dramatically worsen various pathological processes, we consider the situations associated with pathological brain hyperthermia and evaluate its role in acute perturbations of brain functions, neurotoxicity, and neurodegeneration. We also discuss the complexities and limitations in consideration of brain temperature within the frameworks of physiological regulation and homeostasis. While different adaptive mechanisms could, within some limits, compensate for an altered heat balance of the brain, real life often creates situations when this balance could not be compensated, resulting in pathology and life-threatening health complications.
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影响因子：
2.3
作者：
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通讯作者：
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影响因子：
--
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影响因子：
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影响因子：
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