Task-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA.
Task-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA.
复制标题
DOI：
10.1016/j.neuroimage.2013.04.038
复制
发表时间：
2013-10-01
期刊：
影响因子：
5.7
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Xu, Jiansong;Zhang, Sheng;Calhoun, Vince D.;Monterosso, John;Li, Chiang-Shan R.;Worhunsky, Patrick D.;Stevens, Michael;Pearlson, Godfrey D.;Potenza, Marc N.
动物研究表明，不同的功能网络（FN），每一个都有一个独特的时间过程，可能会在共同的大脑区域重叠。为了了解不同的FN如何在人脑中重叠以及重叠FN的时间过程如何被认知任务调制，我们将空间独立成分分析（sICA）应用于功能磁共振成像（fMRI）数据。这些数据是从健康的参与者，而他们执行的视觉任务与参数负荷的注意力和工作记忆。SICA共识别出14个FN，它们在大多数表现出任何功能活动的大脑区域表现出不同程度的重叠。更多的FN重叠在高级联合皮层，包括前和后扣带，楔前叶，枕叶，外侧和内侧额顶叶皮层（FPC）比在初级感觉运动皮层。此外，重叠的FN表现出并发的，但不同的任务相关的时间过程的调制。显示任务相关的向上与向下调制的时程重叠在外侧和内侧FPC和皮质下结构，包括丘脑，纹状体和中脑腹侧被盖区（VTA）的FN。这种任务相关的，并发的，但在相同的大脑区域的时间过程中的相反的变化可能无法检测到目前的分析基于一般线性模型（GLM）。本研究结果表明，多个认知过程可能与共同的大脑区域，并表现出同时，但在认知任务的时间进程不同的调制。
Animal studies indicate that different functional networks (FNs), each with a unique timecourse, may overlap at common brain regions. For understanding how different FNs overlap in the human brain and how the timecourses of overlapping FNs are modulated by cognitive tasks, we applied spatial independent component analysis (sICA) to functional magnetic resonance imaging (fMRI) data. These data were acquired from healthy participants while they performed a visual task with parametric loads of attention and working memory. SICA identified a total of 14 FNs, and they showed different extents of overlap at a majority of brain regions exhibiting any functional activity. More FNs overlapped at the higher-order association cortex including the anterior and posterior cingulate, precuneus, insula, and lateral and medial frontoparietal cortex (FPC) than at the primary sensorimotor cortex. Furthermore, overlapping FNs exhibited concurrent but different task-related modulations of timecourses. FNs showing task-related up- vs. down-modulation of timecourses overlapped at both the lateral and medial FPC and subcortical structures including the thalamus, striatum, and midbrain ventral tegmental area (VTA). Such task-related, concurrent, but opposite changes in timecourses in the same brain regions may not be detected by current analyses based on General-Linear-Model (GLM). The present findings indicate that multiple cognitive processes may associate with common brain regions and exhibit simultaneous but different modulations in timecourses during cognitive tasks.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
Calhoun, VD;Pekar, JJ;Pearlson, GD
通讯作者：
Pearlson, GD
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.7
作者：
Domagalik, Aleksandra;Beldzik, Ewa;Marek, Tadeusz
通讯作者：
Marek, Tadeusz
影响因子：
6.6
作者：
Kim, Dae Il;Mathalon, D. H.;Calhoun, V. D.
通讯作者：
Calhoun, V. D.