Postmortem structural studies of the thalamus in schizophrenia.
Postmortem structural studies of the thalamus in schizophrenia.
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DOI：
10.1016/j.schres.2016.08.007
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发表时间：
2017-03
影响因子：
4.5
通讯作者：
Lewis DA
中科院分区：
文献类型：
--
作者：
Dorph-Petersen KA;Lewis DA
在这篇综述中，我们试图回答以下问题：在目前的文献中的研究结果支持的想法，丘脑皮质功能障碍的精神分裂症是由于丘脑的结构异常？我们基于现有文献的设计无偏见的体视学研究的尸体丘脑精神分裂症患者。因此，所有报告的结果都是基于使用无偏采样原则来确定丘脑或其组成核的体积和/或总细胞数。我们发现了28篇此类论文，涉及26项研究。在一系列表格中，我们列出了来自全丘脑、背内侧核、枕核和前核以及较少研究的丘脑区域的所有阳性和阴性结果。只有四项研究检查了整个丘脑，结果不一致。我们发现位于后丘脑枕的结构变化（体积和细胞数量减少）的证据基本一致。相比之下，丘脑背内侧核的研究结果并不一致，最大和最新的研究通常无法支持早期关于精神分裂症神经元数量较少的报道。因此，精神分裂症丘脑体视学研究的结果支持这样一种观点，即精神分裂症的丘脑-皮质功能障碍可能至少部分归因于枕区的结构改变，这可能损害丘脑对额叶和顶叶中高阶皮质联合区的输入。然而，在得出强有力的结论之前，还需要更多的研究。
In this review, we seek to answer the following question: Do findings in the current literature support the idea that thalamo-cortical dysfunction in schizophrenia is due to structural abnormalities in the thalamus? We base our review on the existing literature of design-unbiased stereological studies of the postmortem thalamus from subjects with schizophrenia. Thus, all reported results are based upon the use of unbiased principles of sampling to determine volume and/or total cell numbers of thalamus or its constituent nuclei. We found 28 such papers covering 26 studies. In a series of tables we list all positive and negative findings from the total thalamus, the mediodorsal, pulvinar and anterior nuclei, as well as less frequently studied thalamic regions. Only four studies examined the entire thalamus and the results were inconsistent. We found largely consistent evidence for structural changes (reduced volume and cell numbers) in the pulvinar located in the posterior thalamus. In contrast, findings in the mediodorsal thalamic nucleus are inconsistent, with the largest and most recent studies generally failing to support earlier reports of a lower number of neurons in schizophrenia. Thus, the current findings of stereological studies of the thalamus in schizophrenia support the idea that thalamo-cortical dysfunction in schizophrenia might be attributable, at least in part, to structural alterations in the pulvinar that could impair thalamic inputs to higher order cortical association areas in the frontal and parietal lobes. However, more studies are needed before robust conclusions can be drawn.
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DOI：
10.1046/j.1365-2818.2001.00958.x
发表时间：
2001-12-01
期刊：
JOURNAL OF MICROSCOPY-OXFORD
影响因子：
--
作者：
Dorph-Petersen, KA;Nyengaard, JR;Gundersen, HJG
通讯作者：
Gundersen, HJG
影响因子：
4.5
作者：
Danos, P;Baumann, B;Bogerts, B
通讯作者：
Bogerts, B
影响因子：
4.5
作者：
Byne, William;Fernandes, Jason;Yiannoulos, Georgia
通讯作者：
Yiannoulos, Georgia
影响因子：
2
作者：
PAKKENBERG, B;GUNDERSEN, HJG
通讯作者：
GUNDERSEN, HJG
影响因子：
14.5
作者：
Kreczmanski, Pawel;Heinsen, Helmut;Schmitz, Christoph
通讯作者：
Schmitz, Christoph