Biographer: web-based editing and rendering of SBGN compliant biochemical networks.

Biographer: web-based editing and rendering of SBGN compliant biochemical networks.
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DOI:
10.1093/bioinformatics/btt159
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发表时间:
2013-06-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
通讯作者:
Handorf T
Handorf T
中科院分区:
其他
文献类型:
--
作者:
Krause F;Schulz M;Ripkens B;Flöttmann M;Krantz M;Klipp E;Handorf T

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动机:在过去的几年中,系统生物学领域知识的快速积累需要先进的,但简单易用的方法,以结构化和易于理解的方式可视化信息。结果如下:我们已经开发了biographer,一个基于网络的渲染器和编辑器的反应网络,它可以作为一个库集成到处理网络相关信息的工具。我们的软件基于新兴的标准系统生物学图形符号实现可视化。它能够导入以各种格式编码的网络,如SBML,SBGN-ML和jSBGN,一种自定义的轻量级交换格式。核心包是用HTML5、CSS和JavaScript实现的,可以在任何基于Web的项目中使用。它具有交互式图形编辑工具和自动图形布局算法。此外,我们还提供了一个独立的图形编辑器和一个Web服务器,其中包含用于导入和导出不同格式的模型和可视化的Web服务等增强功能。可用性:传记作者工具可以在http://biographer.biologie.hu-berlin.de/网站上使用和下载。不同的软件包,包括一个独立于服务器的版本以及一个用于Windows和基于Linux系统的Web服务器,可以在http://code.google.com/p/biographer/上根据开源许可证LGPL获得。联系人:edda. biologie.hu-berlin.de或handorf@physik.hu-berlin.de
Motivation: The rapid accumulation of knowledge in the field of Systems Biology during the past years requires advanced, but simple-to-use, methods for the visualization of information in a structured and easily comprehensible manner. Results: We have developed biographer, a web-based renderer and editor for reaction networks, which can be integrated as a library into tools dealing with network-related information. Our software enables visualizations based on the emerging standard Systems Biology Graphical Notation. It is able to import networks encoded in various formats such as SBML, SBGN-ML and jSBGN, a custom lightweight exchange format. The core package is implemented in HTML5, CSS and JavaScript and can be used within any kind of web-based project. It features interactive graph-editing tools and automatic graph layout algorithms. In addition, we provide a standalone graph editor and a web server, which contains enhanced features like web services for the import and export of models and visualizations in different formats. Availability: The biographer tool can be used at and downloaded from the web page http://biographer.biologie.hu-berlin.de/. The different software packages, including a server-indepenent version as well as a web server for Windows and Linux based systems, are available at http://code.google.com/p/biographer/ under the open-source license LGPL. Contact: edda.klipp@biologie.hu-berlin.de or handorf@physik.hu-berlin.de
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