Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: implications for a proper understanding of type-specific persistent infections.

Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: implications for a proper understanding of type-specific persistent infections.
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配对登记和后续宫颈样本中的人乳头瘤病毒 16 型变种:对正确理解类型特异性持续感染的影响。

DOI:
10.1086/657083
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发表时间:
2010
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Kiviat,NancyB
Kiviat,NancyB
中科院分区:
--
文献类型:
--
作者:
Xi,LongFu;Koutsky,LauraA;Castle,PhilipE;Edelstein,ZoeR;Hulbert,Ayaka;Schiffman,Mark;Kiviat,NancyB

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Prospective studies of the persistence of human papilloma-virus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n= 60), a variant switch occurred in 2 of 11 who had evidence of intervening negativity for HPV-16, compared with 1 of 49 who consistently tested positive (P= .11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections.
通过分子变异分析确定,连续生殖器样本中检测到人乳头瘤病毒 16 型 DNA 并不总是代表持续感染
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