Regional brain differences in cortical thickness, surface area and subcortical volume in individuals with Williams syndrome.
Regional brain differences in cortical thickness, surface area and subcortical volume in individuals with Williams syndrome.
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DOI：
10.1371/journal.pone.0031913
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Thornton-Wells TA
中科院分区：
文献类型：
--
作者：
Meda SA;Pryweller JR;Thornton-Wells TA
威廉姆斯综合征（WS）是一种罕见的遗传性神经发育障碍，其特征是非社交焦虑增加，对声音敏感和过度社交。以前的研究报告了相互矛盾的结果，在WS的区域脑的变化，依赖于只有一种类型的形态学措施（通常是体积）在每个研究。本研究的目的是有助于这一机构的文献，也许阐明了一些这些差异，通过检查并发测量皮质厚度，表面积和皮质下体积WS受试者和典型的发展（TD）控制。对31名WS受试者和50名典型发育对照受试者进行高分辨率MRI扫描。我们使用FreeSurfer软件获得皮质厚度、皮质表面积和皮质下体积的定量区域估计。我们在控制颅内总体积的同时评价了组间ROI差异。在WS组的事后探索性分析中，我们测试了区域大脑变化和贝克焦虑量表评分之间的相关性。与我们的假设相一致，我们检测到组间皮质变化的复杂模式，其中包括较低的表面积与以下皮质区域的较大厚度相结合：中央后回，楔，外侧眶额皮质和舌回。其他皮质区域在一个（但不是两个）形态学测量中显示出组间差异。与TD对照组相比，WS组基底神经节和海马的皮质下体积较低。探索性相关分析显示，焦虑评分与额中回、眶额皮层、额中嘴侧、上级颞回和舌回的灰质表面积呈负相关。我们的研究结果是一致的，与以前的报告显示，在支持社会情感和视觉空间障碍的WS区域的结构改变。然而，我们也能够有效地捕捉新的和复杂的模式，使用表面积和厚度的皮质差异。此外，相关性的结果牵连特定的大脑区域的焦虑水平在WS，与以前的报告调查一般人群中的广泛性焦虑症。
Williams syndrome (WS) is a rare genetic neurodevelopmental disorder characterized by increased non-social anxiety, sensitivity to sounds and hypersociability. Previous studies have reported contradictory findings with regard to regional brain variation in WS, relying on only one type of morphological measure (usually volume) in each study. The present study aims to contribute to this body of literature and perhaps elucidate some of these discrepancies by examining concurrent measures of cortical thickness, surface area and subcortical volume between WS subjects and typically-developing (TD) controls. High resolution MRI scans were obtained on 31 WS subjects and 50 typically developing control subjects. We derived quantitative regional estimates of cortical thickness, cortical surface area, and subcortical volume using FreeSurfer software. We evaluated between-group ROI differences while controlling for total intracranial volume. In post-hoc exploratory analyses within the WS group, we tested for correlations between regional brain variation and Beck Anxiety Inventory scores. Consistent with our hypothesis, we detected complex patterns of between-group cortical variation, which included lower surface area in combination with greater thickness in the following cortical regions: post central gyrus, cuneus, lateral orbitofrontal cortex and lingual gyrus. Additional cortical regions showed between-group differences in one (but not both) morphological measures. Subcortical volume was lower in the basal ganglia and the hippocampus in WS versus TD controls. Exploratory correlations revealed that anxiety scores were negatively correlated with gray matter surface area in insula, OFC, rostral middle frontal, superior temporal and lingual gyrus. Our results were consistent with previous reports showing structural alterations in regions supporting the socio-affective and visuospatial impairments in WS. However, we also were able to effectively capture novel and complex patterns of cortical differences using both surface area and thickness. In addition, correlation results implicate specific brain regions in levels of anxiety in WS, consistent with previous reports investigating general anxiety disorders in the general population.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
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作者：
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DOI：
10.1352/0895-8017(2005)110
发表时间：
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期刊：
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