Determination of the quantitative thallium imaging variables that optimize detection of coronary artery disease.
Determination of the quantitative thallium imaging variables that optimize detection of coronary artery disease.
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确定优化冠状动脉疾病检测的定量铊成像变量。
DOI：
10.1016/s0735-1097(86)80462-4
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发表时间：
1986
影响因子：
24
通讯作者：
Pohost,GM
中科院分区：
文献类型：
--
作者：
Kaul,S;Boucher,CA;Newell,JB;Chesler,DA;Greenberg,JM;Okada,RD;Strauss,HW;Dinsmore,RE;Pohost,GM
虽然运动铊图像的量化以前已经报道过，不同的成像变量的相对价值检测冠状动脉疾病尚未进行分析，在一个大的心脏导管数据的患者组。对325例同时行心导管检查的患者（281例冠心病患者和44例非冠心病患者）进行了局部初始铊摄取、再分布和清除的研究。在其他55例临床正常受试者中定义了正常值。当在每个视图中分析5个心肌节段时，初始铊摄取的敏感性和特异性分别为95%和50%，再分布为60%和87%，清除率为74%和66%。初始铊摄取最敏感但特异性最低（p < 0.001），而再分布最不敏感但特异性最高（p < 0.001）。在冠状动脉疾病概率的数学模型中加入再分布并没有改变敏感性，但特异性从50%增加到70%（p < 0.001）。一旦考虑到初始摄取和再分布，心肌铊清除率在相关性中没有提供额外的改善。从分析中排除每个视图中的两个基底节段将特异性从70%增加到80%（p < 0.001），而不影响灵敏度。在15例（5%）使用该方法未检测到冠状动脉疾病的患者中，无左主干病变，10例（67%）有1支血管病变。与使用单一变量相比，从运动铊图像的量化导出的变量的组合提供了用于检测冠状动脉疾病的优越的上级灵敏度和特异性。
Although quantification of exercise thallium images has been previously reported, the relative value of different imaging variables for detection of coronary artery disease has not been analyzed in a large group of patients with cardiac catheterization data. Regional initial thallium uptake, redistribution and clearance on thallium study were measured in 325 patients also undergoing cardiac catheterization (281 patients with and 44 patients without coronary artery disease). Normal values were defined in 55 other clinically normal subjects. When five myocardial segments were analyzed in each view, the respective values for sensitivity and specificity were 95 and 50% for initial thallium uptake, 60 and 87% for redistribution and 74 and 66% for clearance. Initial thallium uptake was the most sensitive but least specific (p < 0.001), whereas redistribution was the least sensitive and most specific (p < 0.001).Using stepwise logistic regression analysis, the best correlate of coronary artery disease was initial thallium uptake. Addition of redistribution to a mathematical model of the probability of coronary artery disease did not alter sensitivity, but increased specificity from 50 to 70% (p < 0.001). Once initial uptake and redistribution were considered, myocardial thallium clearance provided no additional improvement in the correlation. Excluding the two basal segments in each view from the analysis increased the specificity from 70 to 80% (p < 0.001) without affecting sensitivity. Of the 15 patients (5%) with coronary disease not detected using this approach, none had left main disease and 10 (67%) had one vessel disease. A combination of variables derived from quantification of exercise thallium images provides a superior sensitivity and specificity for the detection of coronary artery disease compared with the use of a single variable.
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对底特律儿童血铅水平升高的调查。
DOI：
10.1080/00039896.1979.10667386
发表时间：
1979
期刊：
Archives of environmental health
影响因子：
--
作者：
G. T. Haar;L. Chadzynski
通讯作者：
L. Chadzynski
铅暴露大鼠的眼内脑组织移植物、大脑和血液中的铅、锌和铜水平。
影响因子：
3.8
作者：
Björklund,H;Lind,B;Piscator,M;Hoffer,B;Olson,L
通讯作者：
Olson,L
铅、镉和汞引起的交感神经纤维的不同形态变化。
影响因子：
8.3
作者：
Björklund,H;Hoffer,B;Olson,L;Seiger,A
通讯作者：
Seiger,A
DOI：
10.1039/an9780300714
发表时间：
1978
期刊：
The Analyst
影响因子：
--
作者：
M. Stoeppler;K. Brandt;T. Rains
通讯作者：
T. Rains
牛奶饮食对大鼠铅代谢的影响。
影响因子：
8.3
作者：
D. Kello;K. Kostial
通讯作者：
K. Kostial