Dispositional optimism predicts placebo analgesia.
Dispositional optimism predicts placebo analgesia.
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DOI：
10.1016/j.jpain.2010.02.014
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
France CR
中科院分区：
文献类型：
--
作者：
Geers AL;Wellman JA;Fowler SL;Helfer SG;France CR
基于先前的研究确定性格乐观是安慰剂反应的一个预测因素，本研究验证了一个假设，即高度乐观的个体更有可能对安慰剂止痛药做出反应。在冷压力任务之前，乐观主义者和悲观主义者被随机分配到安慰剂期望条件或没有期望条件。在冷压任务之前和期间记录血压和心率，并在任务结束后立即获得参与者的疼痛评分和期望。对期望操纵的分析表明，安慰剂指导在冷压过程中成功地改变了参与者的期望。支持主要假设，性格乐观与安慰剂条件下较低的疼痛评分有关，而在对照条件下没有。因为性格乐观可以改变安慰剂对实验室疼痛的反应，未来的研究应该检查这种个体差异因素在患者对临床疼痛的药物和非药物治疗的反应中可能发挥的潜在作用。
Based upon prior research identifying dispositional optimism as a predictor of placebo responding, the present study tested the hypothesis that individuals high in optimism would be more likely to respond to a placebo analgesic. Optimists and pessimists were randomly assigned to a placebo expectation condition or a no expectation condition prior to a cold pressor task. Blood pressure and heart rate were recorded before and during the cold pressor task, and participant ratings of pain and expectations were obtained immediately after the task. Analysis of the expectation manipulation revealed that the placebo instruction was successful in altering participant expectancy during the cold pressor. Supporting the main hypothesis, dispositional optimism was associated with lower pain ratings in the placebo condition but not in the control condition. Because dispositional optimism can alter placebo responding to laboratory pain, future studies should examine the potential role that this individual difference factor may play in patient responsivity to pharmacological and non-pharmacological treatments for clinical pain.
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