Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study.
Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study.
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DOI：
10.1186/s12877-022-02939-2
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发表时间：
2022-03-28
期刊：
影响因子：
4.1
通讯作者：
Ninomiya T
中科院分区：
文献类型：
--
作者：
Kimura Y;Yoshida D;Ohara T;Hata J;Honda T;Hirakawa Y;Shibata M;Oishi E;Sakata S;Furuta Y;Chen S;Uchida K;Nakao T;Kitazono T;Ninomiya T
一些前瞻性的西方研究报告了蔬菜和水果摄入量与痴呆风险的负相关性。然而，亚洲人的流行病学证据有限。本研究调查了日本社区中蔬菜、水果及其营养素摄入量与痴呆症及其亚型发病风险的关系。共有1071名参与者（452名男性和619名女性）年龄≥60岁，基线时无痴呆，前瞻性随访24年。蔬菜、水果和营养素的摄入量在基线时使用70项半定量食物频率问卷进行评估，并按性别分别分为四分位数。结果测量是痴呆及其亚型的发展，即阿尔茨海默病（AD）和血管性痴呆（VaD）。使用考克斯比例风险模型计算痴呆事件的风险估计。在长期随访期间，464名受试者发生痴呆，其中286人患有AD，144人患有VaD。在调整混杂因素后，较高的蔬菜摄入量逐渐与痴呆和AD的风险降低相关（均P趋势< 0.05），但与VaD无关。蔬菜摄入量最高四分位数的受试者患痴呆症和AD的风险分别比最低四分位数的受试者低27%和31%。随着维生素A、核黄素、维生素C、镁、钙和钾的摄入量增加，痴呆的风险显著降低（所有P趋势< 0.05）。总膳食纤维摄入量较高的受试者倾向于降低总痴呆症的风险（P趋势= 0.07）。同时，水果摄入量与痴呆及其亚型的风险之间没有显着关联。在日本老年人中，蔬菜及其营养成分的摄入量较高与痴呆症的风险较低有关。富含蔬菜的饮食可能有助于降低亚洲人患痴呆症的风险。在线版本包含补充材料，可通过10.1186/s12877-022-02939-2获得。
Several prospective Western studies have reported an inverse association of vegetable and fruit intake with dementia risk. However, there is limited epidemiologic evidence in Asians. This study investigated the association of intakes of vegetables, fruits, and their nutrients on the risk of incident dementia and its subtypes in a Japanese community. A total of 1071 participants (452 men and 619 women) aged ≥60 years without dementia at baseline were prospectively followed up for 24 years. Intakes of vegetables, fruits, and nutrients were evaluated using a 70-item semiquantitative food frequency questionnaire at baseline and were categorized into quartiles separately by gender. The outcome measure was the development of dementia and its subtypes—namely, Alzheimer’s disease (AD) and vascular dementia (VaD). The risk estimates of incident dementia were computed using a Cox proportional hazards model. During the long-term follow-up period, 464 subjects developed dementia, of whom 286 had AD and 144 had VaD. Higher vegetable intake was associated gradually with lower risk of developing dementia and AD (both P-trend < 0.05), but not VaD, after adjusting for confounders. Subjects allocated the highest quartile of vegetable intake had 27 and 31% lower risk of dementia and AD, respectively, than those with the lowest quartile. The risk of dementia decreased significantly with higher intakes of vitamin A, riboflavin, vitamin C, magnesium, calcium, and potassium (all P-trend < 0.05). Subjects with higher total dietary fiber intake tended to be at decreased risk for total dementia (P-trend = 0.07). Meanwhile, there were no significant associations between fruit intake and the risk of dementia and its subtypes. Higher intakes of vegetables and their constituent nutrients were associated with a lower risk of dementia in Japanese older adults. A diet rich in vegetables may be beneficial in reducing the dementia risk in Asians. The online version contains supplementary material available at 10.1186/s12877-022-02939-2.
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影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
7.2
作者：
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通讯作者：
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作者：
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作者：
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作者：
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通讯作者：
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