Glyphosate resistance: state of knowledge.
Glyphosate resistance: state of knowledge.
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DOI：
10.1002/ps.3743
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发表时间：
2014-09
影响因子：
4.1
通讯作者：
Gaines, Todd A.
中科院分区：
文献类型：
--
作者：
Sammons, Robert Douglas;Gaines, Todd A.
关键词：
对草甘膦抗性机制的研究增加了目前对除草剂抗性机制的理解。到目前为止，EPSPS（5-烯醇式丙酮基莽草酸-3-磷酸合成酶）的单密码子非同义突变很少见，并且相对于其他除草剂作用模式靶点突变，对草甘膦的抗性强度异常弱。然而，可能的是，杂草将出现两个密码子的EPSPS的非同义突变，以产生赋予对草甘膦更大抗性的酶。今天，靶基因复制是一种常见的草甘膦抗性机制，并可能成为开发任何抗性性状的基本过程。基于在几个物种中的竞争和底物选择性研究，草甘膦的快速液泡隔离通过转运机制发生。相反，由于叶绿体需要转运蛋白来摄取重要的代谢物，因此与两个质体膜相关的转运蛋白可以单独或一起成功地阻断草甘膦递送。基于有限草甘膦剂量和叶绿体加载所需的有限时间的模型为理解独特的不同机制如何有助于整体草甘膦抗性奠定了基础。
Studies of mechanisms of resistance to glyphosate have increased current understanding of herbicide resistance mechanisms. Thus far, single-codon non-synonymous mutations of EPSPS (5-enolypyruvylshikimate-3-phosphate synthase) have been rare and, relative to other herbicide mode of action target-site mutations, unconventionally weak in magnitude for resistance to glyphosate. However, it is possible that weeds will emerge with non-synonymous mutations of two codons of EPSPS to produce an enzyme endowing greater resistance to glyphosate. Today, target-gene duplication is a common glyphosate resistance mechanism and could become a fundamental process for developing any resistance trait. Based on competition and substrate selectivity studies in several species, rapid vacuole sequestration of glyphosate occurs via a transporter mechanism. Conversely, as the chloroplast requires transporters for uptake of important metabolites, transporters associated with the two plastid membranes may separately, or together, successfully block glyphosate delivery. A model based on finite glyphosate dose and limiting time required for chloroplast loading sets the stage for understanding how uniquely different mechanisms can contribute to overall glyphosate resistance.
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影响因子：
2.5
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影响因子：
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