Cost-effective and rapid blood analysis on a cell-phone.

Cost-effective and rapid blood analysis on a cell-phone.
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DOI:
10.1039/c3lc41408f
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发表时间:
2013-04-07
期刊:
影响因子:
6.1
通讯作者:
Ozcan A
Ozcan A
中科院分区:
工程技术1区
文献类型:
--
作者:
Zhu H;Sencan I;Wong J;Dimitrov S;Tseng D;Nagashima K;Ozcan A

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我们展示了一种安装在手机上的紧凑且经济实惠的成像细胞仪平台,用于测量人体血液样本中的红细胞和白细胞密度以及血红蛋白浓度。血液样本的荧光和亮场图像是通过手机上单独的光学附件捕获的,并通过手机上运行的定制开发的智能应用程序进行快速处理,用于计算血细胞和确定血红蛋白浓度。我们使用匿名人体血液样本评估了这个基于手机的血液分析平台的性能,并获得了与标准台式血细胞分析仪相当的结果。测试结果可以存储在手机存储器上,也可以传输到中央服务器,即使在现场环境中也能提供远程诊断机会。
We demonstrate a compact and cost-effective imaging cytometry platform installed on a cell-phone for the measurement of the density of red and white blood cells as well as hemoglobin concentration in human blood samples. Fluorescent and bright-field images of blood samples are captured using separate optical attachments to the cell-phone and are rapidly processed through a custom-developed smart application running on the phone for counting of blood cells and determining hemoglobin density. We evaluated the performance of this cell-phone based blood analysis platform using anonymous human blood samples and achieved comparable results to a standard bench-top hematology analyser. Test results can either be stored on the cell-phone memory or be transmitted to a central server, providing remote diagnosis opportunities even in field settings.
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