Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress.
Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress.
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DOI：
10.1016/j.bbi.2014.07.018
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发表时间：
2014-11
影响因子：
15.1
通讯作者：
Rohleder, Nicolas
中科院分区：
文献类型：
--
作者：
McInnis, Christine M.;Thoma, Myriam V.;Gianferante, Danielle;Hanlin, Luke;Chen, Xuejie;Breines, Juliana G.;Hong, Suzi;Rohleder, Nicolas
超重和肥胖的人约占美国人口的三分之二，他们患一系列疾病的风险更高。这种增加的风险可能部分是由于这一组内的不良适应应激反应，包括高度的低度炎症和HPA轴不习服。在这项研究中，我们测试了肥胖、血浆白介素6(IL-6)和HPA轴对重复应激反应的关系。67名健康参与者连续两天接受特里尔社会压力测试(TSST)。分别于治疗前、治疗后1、10、30、60、120分钟采集唾液进行皮质醇测定，并于治疗前、治疗后30分钟、120分钟采血测定血浆IL-6水平。应激暴露后皮质醇和IL-6在两天均显著升高(皮质醇：F=38，p<；0.001；IL-6：F=90.8；p<；0.001)，重复暴露与皮质醇习惯性(F=8.2p<；0.001)和IL-6敏化(F=5.2p=0.022)相关。体重指数和体脂与皮质醇对重复应激的高反应(体重指数：β=0.34；p=0.014；体脂：β=0.29；p=0.045)和IL-6对重复应激的高反应(体重指数：β=0.27p=0.044；体脂：β=0.37；p=0.006)相关。总而言之，肥胖程度较高的个体表现出较低的HPA轴习惯化效率以及对反复急性应激的IL-6反应敏化。这些发现指出了超重人类的不适应压力反应模式，通过暴露在更高水平的炎症介质中，这可能部分解释了与超重和/或肥胖相关的疾病。
Overweight and obese individuals, who comprise approximately two-thirds of the U.S. population, are at increased risk for developing a range of diseases. This increased risk may be due in part to maladaptive stress responses within this group, including heightened low-grade inflammation and HPA axis non-habituation. In this study we tested the relationship between adiposity, plasma interleukin-6 (IL-6) and HPA axis responses to repeated stress. Sixty-seven healthy participants were exposed to the Trier Social Stress Test (TSST) on two consecutive days. We collected saliva for cortisol measurements at baseline and at 1, 10, 30, 60 and 120 minutes post-TSST, and blood for plasma IL-6 measurements at baseline and 30 and 120 minutes post-TSST. Stress exposure induced significant increases of cortisol and IL-6 on both days (cortisol: F=38, p<0.001; IL-6: F=90.8; p<0.001), and repeated exposure was related with cortisol habituation (F=8.2; p<0.001) and IL-6 sensitization (F=5.2; p=0.022). BMI and body fat were related with higher cortisol responses to repeated stress (BMI: beta=0.34; p=0.014; body fat: beta=0.29; p=0.045), and with higher IL-6 responses to repeated stress (BMI: beta=0.27, p=0.044; body fat: beta=0.37; p=0.006). Taken together, individuals with higher measures of adiposity showed less efficient HPA axis habituation as well as sensitization of IL-6 responses to repeated acute stress. These findings point to maladaptive stress response patterns in overweight humans, which, through exposure to higher levels of inflammatory mediators, might partially explain diseases related with overweight and/or obesity.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.7
作者：
Jones A;McMillan MR;Jones RW;Kowalik GT;Steeden JA;Deanfield JE;Pruessner JC;Taylor AM;Muthurangu V
通讯作者：
Muthurangu V
影响因子：
2.6
作者：
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通讯作者：
Brydon, Lena
影响因子：
15.1
作者：
Fagundes, Christopher P.;Glaser, Ronald;Hwang, Beom Seuk;Malarkey, William B.;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.
影响因子：
3.7
作者：
Benson, S.;Arck, P. C.;Elsenbruch, S.
通讯作者：
Elsenbruch, S.