Regulation of plasma growth hormone-binding proteins in health and disease.
Regulation of plasma growth hormone-binding proteins in health and disease.
复制标题
健康和疾病中血浆生长激素结合蛋白的调节。
DOI：
10.1016/0026-0495(89)90108-x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Amburn,K
中科院分区：
文献类型：
--
作者：
Baumann,G;Shaw,MA;Amburn,K
生长激素（GH）结合蛋白（BP）是近年来在人体血浆中发现的一种新的生长激素结合蛋白。主要BP与GH受体相关，可能对应于受体的细胞外部分。BP影响GH稳态和作用的几个方面。因此，它们在血液中的水平和活性成为整体GH生理学的重要变量。然而，迄今为止，很少有人知道GH-BP在健康和疾病中的调节。为了获得关于这一点的初步信息，GH-BP活性在124例具有各种生理和病理条件的受试者的血浆中进行了检查。选择这些条件以提供基本生理数据（男性、女性、儿童、年龄、妊娠），并研究异常GH生理学参与的关键疾病状态（肝硬化、尿毒症、感染、肢端肥大症）。标准化GH结合试验用于测量BP活性作为BP水平的指标。主要的高亲和力BP（峰II）和次要的低亲和力BP（峰I）在所有组中均显示出相当大的个体差异。新生儿的两种血压水平最低，但到1岁时，血压水平有所增加，并在第七个十年中保持相当稳定。在1至20岁的男性中，主（峰值II）BP呈轻微上升趋势，而次（峰值I）BP中度下降。肝硬化患者的血压变化最大，尿毒症患者的结合峰II降低，但峰I未降低。肢端肥大症患者的BP均未受到影响。我们的结论是，BP活性在血浆中是很好地保存在大多数情况下，但存在很大的个体差异。BP活动在生命的第一年急剧增加。这两个BP似乎是不同的调节，峰I，但不是峰II，显示性激素依赖的证据。高亲和力（峰II）BP携带80%至90%的复合GH。我们建议定义一个单位的BP活性为1 mL正常成人血浆中所含的BP活性。在本报告中使用的分析条件下，1个单位对应于结合GH分数30%。
Binding proteins (BP) for growth hormone (GH) have recently been discovered in human plasma. The main BP is related to the GH receptor and probably corresponds to the extracellular portion of the receptor. The BP influence several aspects of GH homeostasis and action. Their level and activity in blood, therefore, become important variables in overall GH physiology. However, to date little is known about the regulation of GH-BP in health and disease. To gain initial information about this point, GH-BP activity was examined in the plasma of 124 subjects with various physiologic and pathologic conditions. The conditions were selected to provide basic physiologic data (men, women, children, age, pregnancy) and to investigate key disease states attended by abnormal GH physiology (liver cirrhosis, uremia, infection, acromegaly). A standardized GH binding assay was used to measure BP activity as an index of BP levels. Both the principal, high affinity BP (peak II) and the minor, low affinity BP (peak I) showed considerable individual variation in all groups. Neonates had the lowest levels of both BPs, but by the age of 1 year the levels had increased and remained fairly stable through the seventh decade. In males but not females between the ages of 1 and 20 years, the main (peak II) BP showed a slight upward trend, whereas the minor (peak I) BP declined moderately. Patients with cirrhosis showed the most variation in both BP, and uremic patients demonstrated decreased peak II, but not peak I, binding. Neither BP was affected in acromogaly. We conclude that BP activity in plasma is well conserved in most conditions, but substantial individual variability exists. BP activity increases dramatically during the first year of life. The two BPs appear to be differently regulated, with peak I, but not peak II, showing evidence for sex hormone dependence. The high affinity (peak II) BP carries 80% to 90% of the complexed GH. We propose to define one unit of BP activity as that contained in 1 mL of normal adult plasma. Under the conditions of analysis used in this report, one unit corresponds to a bound GH fraction of 30%.
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DOI：
--
发表时间：
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期刊：
International journal of fertility
影响因子：
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作者：
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DOI：
10.1080/01971528608060462
发表时间：
1986
期刊：
Journal of immunoassay
影响因子：
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作者：
Baumann,G;Amburn,K
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影响因子：
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W. Daughaday;B. Trivedi;Brian A. Andrews
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影响因子：
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作者：
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