8-hydroxy-dipropylaminotetralin promotes neural plasticity in epileptic rats with depression.
8-hydroxy-dipropylaminotetralin promotes neural plasticity in epileptic rats with depression.
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DOI：
10.3969/j.issn.1673-5374.2012.08.001
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发表时间：
2012-03-15
影响因子：
6.1
通讯作者：
Shen Y
中科院分区：
文献类型：
--
作者：
Yang P;Sun M;Li L;Shen Y
本实验观察了慢性匹罗卡品颞叶癫痫合并抑郁的大鼠模型。抗5-溴脱氧尿苷免疫荧光染色和Timms染色显示模型组大鼠海马齿状回神经发生和苔藓纤维出芽增加。海马齿状回内的神经发生进一步增强，而苔藓纤维发芽减少模型大鼠单独服用卡马西平或与5-羟色胺1A受体激动剂，8-羟基-二丙氨基四氢萘（0.1和1毫克/公斤）。在各组中，在接受卡马西平与1 mg/kg 8-羟基-二丙氨基四氢萘联合给药的大鼠中，效果最显著。因此，大剂量8-羟基-二丙氨基四氢萘可改善癫痫伴抑郁大鼠的神经可塑性。
Rats with chronic pilocarpine-induced temporal lobe epilepsy complicated with depression were studied. Anti-5-bromodeoxyuridine immunofluorescence staining and Timms staining showed that neurogenesis within the hippocampal dentate gyrus and mossy fiber sprouting were increased in model rats. Neurogenesis within the hippocampal dentate gyrus was further enhanced, while mossy fiber sprouting was decreased in model rats administered carbamazepine alone or in combination with the 5-hydroxytryptamine 1A receptor agonist, 8-hydroxy-dipropylaminotetralin (0.1 and 1 mg/kg). Among the groups, the effect was the most significant in rats receiving carbamazepine in conjunction with 1 mg/kg 8-hydroxy-dipropylaminotetralin. Thus, high dose 8-hydroxy-dipropylaminotetralin can improve neural plasticity in epileptic rats with depression.
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影响因子：
2.2
作者：
Arida, RM;Scorza, FA;Cavalheiro, EA
通讯作者：
Cavalheiro, EA
影响因子：
--
作者：
MENDEZ, MF;CUMMINGS, JL;BENSON, DF
通讯作者：
BENSON, DF
影响因子：
2.9
作者：
Radley, JJ;Jacobs, BL
通讯作者：
Jacobs, BL
影响因子：
2.9
作者：
Radley, JJ;Jacobs, BL
通讯作者：
Jacobs, BL
影响因子：
5.6
作者：
Pineda E;Shin D;Sankar R;Mazarati AM
通讯作者：
Mazarati AM