IgM, Fc mu Rs, and malarial immune evasion.
IgM, Fc mu Rs, and malarial immune evasion.
复制标题
DOI：
10.4049/jimmunol.1000203
复制
发表时间：
2010-05-01
期刊：
影响因子：
--
通讯作者：
Pleass RJ
中科院分区：
文献类型：
--
作者：
Czajkowsky DM;Salanti A;Ditlev SB;Shao Z;Ghumra A;Rowe JA;Pleass RJ
“这是一个作者制作的版本的手稿接受发表在免疫学杂志（JI）。美国免疫学家协会(AAI)JI的出版商拥有本手稿的版权。这一版本的手稿尚未由联合执行进行复制编辑或编辑校对;因此，它可能与联合执行发表的最后版本（在线和印刷版）不同。AAI（JI）对作者制作的手稿版本或美国国立卫生研究院或任何其他第三方从中衍生的任何版本中的错误或遗漏不承担责任。记录的最终可引用版本可在www.jimmunol.org上找到。免疫球蛋白M（IgM）是一种祖先抗体，存在于从鲨鱼到哺乳动物的所有有颌脊椎动物中。这种古老的祖先是疟疾寄生虫（疟原虫属）所共有的，它们感染与它们共同进化的所有种类的陆生脊椎动物。IgM是脊椎动物免疫球蛋白中研究最少、最神秘的一种，最近已被证明与疟疾寄生虫恶性疟原虫（Plasmodium falciparum）有密切关系。在这里，我们讨论了这种关联可能是如何产生的，建立在最近确定的人类IgM五聚体的结构上，以及这种相互作用如何影响寄生虫的生存，特别是根据刚刚发现的Fcμ受体（FcµR）定位于B和T细胞表面。由于这种寄生虫可能利用与IgM的相互作用，不仅限制免疫检测，而且在检测时操纵免疫应答，因此更好地了解这种关联可能对开发改进的疫苗或疫苗接种策略至关重要。
"This is an author-produced version of a manuscript accepted for publication in The Journal of Immunology (The JI). The American Association of Immunologists, Inc. (AAI), publisher of The JI, holds the copyright to this manuscript. This version of the manuscript has not yet been copyedited or subjected to editorial proofreading by The JI; hence, it may differ from the final version published in The JI (online and in print). AAI (The JI) is not liable for errors or omissions in this author-produced version of the manuscript or in any version derived from it by the U.S. National Institutes of Health or any other third party. The final, citable version of record can be found at www.jimmunol.org." Immunoglobulin M (IgM) is an ancestral antibody class found in all jawed vertebrates from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied, and most enigmatic of the vertebrate immunoglobulins has recently been shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. Here we discuss how this association might come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just discovered Fcμ-receptor (FcµR) localized to B and T cell surfaces. As this parasite may exploit an interaction with IgM to not only limit immune detection but also manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.
登录
查看更多内容
影响因子：
5.6
作者：
Khunrae, Pongsak;Philip, Judith M. D.;Bull, Duncan R.;Higgins, Matthew K.
通讯作者：
Higgins, Matthew K.
影响因子：
64.5
作者：
BARUCH, DI;PASLOSKE, BL;HOWARD, RJ
通讯作者：
HOWARD, RJ
影响因子：
56.9
作者：
Flick, K;Scholander, C;Wahlgren, M
通讯作者：
Wahlgren, M
影响因子：
56.9
作者：
Fried, M;Duffy, PE
通讯作者：
Duffy, PE
影响因子：
64.8
作者：
HARTE, PG;COOKE, A;PLAYFAIR, JHL
通讯作者：
PLAYFAIR, JHL