Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex.
Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex.
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DOI：
10.1016/j.neuron.2017.06.042
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发表时间：
2017-08-02
期刊：
影响因子：
16.2
通讯作者：
Jessell TM
中科院分区：
文献类型：
--
作者：
Miri A;Warriner CL;Seely JS;Elsayed GF;Cunningham JP;Churchland MM;Jessell TM
通过损伤或药物失活来阻断运动皮层输出已经确定了需要运动皮层的运动。然而，运动皮层在运动执行过程中何时以及如何影响肌肉活动仍然悬而未决。我们通过测量和扰动运动皮层活动以及小鼠在两次前肢运动期间的肌电图来解决这一模糊性，这两次前肢运动对皮层参与的要求不同。快速光遗传学沉默和电刺激表明，连接运动皮层和脊髓运动神经元的短潜伏通路在一种行为期间被选择性激活。对运动皮层活动的分析揭示了神经元之间放电模式协调的行为之间的巨大变化，这可以解释这种不同的影响。因此，我们的结果表明，运动皮层输出模式的变化能够实现短潜伏期效应器通路的行为选择性参与。我们的研究结果暗示的运动皮质影响模型有助于协调之前对运动皮质功能的观察。米里等人。在同步肌电图过程中测量和扰乱运动皮层活动，以揭示运动皮层参与短潜伏效应器通路的行为选择性。输出激发模式之间相关性的变化似乎调节了这种选择性。
Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor cortical activity together with electromyography in mice during two forelimb movements that differ in their requirement for cortical involvement. Rapid optogenetic silencing and electrical stimulation indicated that short-latency pathways linking motor cortex with spinal motor neurons are selectively activated during one behavior. Analysis of motor cortical activity revealed a dramatic change between behaviors in the coordination of firing patterns across neurons that could account for this differential influence. Thus, our results suggest that changes in motor cortical output patterns enable a behaviorally-selective engagement of short-latency effector pathways. The model of motor cortical influence implied by our findings helps reconcile previous observations on the function of motor cortex. Miri et al. measured and perturbed motor cortical activity during simultaneous electromyography to reveal behavioral selectivity in the engagement of short-latency effector pathways by motor cortex. Changes in the correlation among output firing patterns appear to mediate this selectivity.
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影响因子：
64.8
作者：
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通讯作者：
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通讯作者：
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Vibrissa运动皮层活性抑制对侧搅拌行为。
影响因子：
25
作者：
Ebbesen CL;Doron G;Lenschow C;Brecht M
通讯作者：
Brecht M