Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder.
Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder.
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DOI：
10.1038/srep35361
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发表时间：
2016-10-13
影响因子：
4.6
通讯作者：
Yamasoba T
中科院分区：
文献类型：
--
作者：
Kikuta S;Matsumoto Y;Kuboki A;Nakayama T;Asaka D;Otori N;Kojima H;Sakamoto T;Akinori K;Kanaya K;Ueha R;Kagoya R;Nishijima H;Toma-Hirano M;Kikkawa Y;Kondo K;Tsunoda K;Miyaji T;Yamaguchi T;Kataoka K;Mori K;Yamasoba T
嗅觉几乎丧失可能是由于传导和/或神经嗅觉障碍。然而，选择性地检测神经障碍的嗅觉测试尚未建立。我们研究了静脉注射气味的感觉反应的起始潜伏期是否可以检测人类和小鼠的神经疾病。我们发现，慢性鼻窦炎患者术前对静脉气味识别的潜伏期越长，鼻窦手术后嗅觉症状的恢复越差。嗅觉感觉神经元（OSN）对静脉内气味的反应，使用来自OSN轴突末梢的突触荧光素信号的起始潜伏期在OSN数量减少（神经障碍）的小鼠中延迟，但在粘液增加或鼻旁通路阻断（传导障碍）的小鼠中不延迟。此外，发病潜伏期的增加与成熟OSN数量的减少相关。较长的发病潜伏期静脉内气味注射是一个有用的生物标志物的存在和严重程度的嗅觉障碍与神经病因。
A near loss of smell may result from conductive and/or neural olfactory disorders. However, an olfactory test to selectively detect neural disorders has not been established. We investigated whether onset latency of sensory response to intravenous odor injection can detect neural disorders in humans and mice. We showed that longer preoperative onset latency of odor recognition to intravenous odor in patients with chronic rhinosinusitis predicted worse recovery of olfactory symptoms following sinus surgery. The onset latency of the olfactory sensory neuron (OSN) response to intravenous odor using synaptopHluorin signals from OSN axon terminals was delayed in mice with reduced numbers of OSNs (neural disorder) but not with increased mucus or blocked orthonasal pathways (conductive disorders). Moreover, the increase in onset latency correlated with the decrease in mature OSN numbers. Longer onset latency to intravenous odor injection is a useful biomarker for presence and severity of olfactory disorders with neural etiology.
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影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M
DOI：
10.1007/bf00453761
发表时间：
1986-01-01
期刊：
ARCHIVES OF OTO-RHINO-LARYNGOLOGY
影响因子：
--
作者：
HASEGAWA, S;YAMAGISHI, M;NAKANO, Y
通讯作者：
NAKANO, Y
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影响因子：
5.5
作者：
Doyle WJ;Skoner DP;Gentile D
通讯作者：
Gentile D
影响因子：
3.4
作者：
Hopkins, Claire;Browne, John P.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
16.2
作者：
Bozza, T;McGann, JP;Wachowiak, M
通讯作者：
Wachowiak, M