History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China.
History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China.
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DOI：
10.1016/j.lungcan.2013.06.019
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发表时间：
2013-09
期刊：
影响因子：
5.3
通讯作者：
Lan, Qing
中科院分区：
文献类型：
--
作者：
Hosgood, H. Dean, III;Chapman, Robert S.;He, Xingzhou;Hu, Wei;Tian, Linwei;Liu, Larry Z.;Lai, Hong;Chen, Wei;Rothman, Nathaniel;Lan, Qing
慢性肺部疾病史和家庭取暖和烹饪用煤是肺癌的既定危险因素;然而，很少有研究能够同时探讨这些危险因素。中国宣威市是中国肺癌发病率最高的地区之一，大多数居民都经历了大量的家庭煤烟暴露。采用基于人群的病例对照研究，包括498例肺癌病例和498例年龄匹配的对照，我们评估了与煤烟暴露和慢性肺部疾病史（包括慢性阻塞性肺病（COPD）、哮喘、结核病（TB）、慢性支气管炎和肺气肿）相关的肺癌风险。通过调整潜在混杂因素的条件Logistic回归计算比值比（OR）和95%置信区间（CI）。我们观察到男性（OR=14.2; 95%CI =4.3 - 46.9）、女性（OR=2.6; 95%CI =1.1 - 6.3）、吸烟者（OR=12.7; 95%CI =3.5 - 45.8）和非吸烟者（OR=2.6; 95%CI =1.1 - 6.4）中有任何慢性肺部疾病史的肺癌风险增加。具体而言，肺结核（OR=83.7; 95%CI =11.0 - 634.7）、COPD（OR=3.2; 95%CI =1.7 - 6.0）、肺气肿和慢性支气管炎（OR=3.3; 95%CI =1.7 - 6.4）与风险增加相关。这些发现表明，慢性肺部疾病史也可能增加室内煤烟暴露人群患肺癌的风险。
History of chronic lung diseases and household coal use for heating and cooking are established risk factors of lung cancer; however, few studies have been able to explore these risk factors simultaneously. Xuanwei, China, has some of the highest rates of lung cancer in China and most residents experience substantial in-home coal smoke exposures. Using a population-based case-control study of 498 lung cancer cases and 498 age-matched controls, we evaluated the risk of lung cancer in relation to coal smoke exposure and history of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), chronic bronchitis, and emphysema. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression adjusting for potential confounders. We observed an increased risk of lung cancer with history of any chronic lung disease among males (OR=14.2; 95%CI =4.3 to 46.9), females (OR=2.6; 95%CI =1.1 to 6.3), smokers (OR=12.7; 95%CI =3.5 to 45.8), and nonsmokers (OR=2.6; 95%CI =1.1 to 6.4). Specifically, TB (OR=83.7; 95%CI =11.0 to 634.7), COPD (OR=3.2; 95%CI =1.7 to 6.0), and emphysema and chronic bronchitis (OR=3.3; 95%CI =1.7 to 6.4) were associated with increased risks. These findings suggest that history of chronic lung diseases may also increase risk of lung cancer in populations with indoor coal smoke exposures.
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影响因子：
6.4
作者：
Engels, Eric A.;Shen, Min;Chapman, Robert S.;Pfeiffer, Ruth M.;Yu, Ying-Ying;He, Xingzhou;Lan, Qing
通讯作者：
Lan, Qing
影响因子：
8.8
作者：
Hosgood, H. D., III;Chapman, R.;Shen, M.;Blair, A.;Chen, E.;Zheng, T.;Lee, K-M;He, X.;Lan, Q.
通讯作者：
Lan, Q.
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
5.3
作者：
Sasco, AJ;Secretan, MB;Straif, K
通讯作者：
Straif, K
影响因子：
2.4
作者：
Galeone, Carlotta;Pelucchi, Claudio;Hu, Jinfu
通讯作者：
Hu, Jinfu