Tuberculosis and subsequent risk of lung cancer in Xuanwei, China.
Tuberculosis and subsequent risk of lung cancer in Xuanwei, China.
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DOI：
10.1002/ijc.24042
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发表时间：
2009-03-01
影响因子：
6.4
通讯作者：
Lan, Qing
中科院分区：
文献类型：
--
作者：
Engels, Eric A.;Shen, Min;Chapman, Robert S.;Pfeiffer, Ruth M.;Yu, Ying-Ying;He, Xingzhou;Lan, Qing
烟草和煤烟造成的室内空气污染是中国宣威县农村肺癌的主要原因。结核病被认为会增加肺癌的风险，但以前的研究数据有限。我们对宣威市42,422名农民的回顾性队列研究数据进行了分析。1992年，调查人员进行了一份标准化的问卷调查，其中包括一生的病史，包括结核病。受试者从1976年开始接受随访，直到1996年确定肺癌死亡。我们使用比例风险回归来评估结核病和随后的肺癌死亡率之间的关系。随访期间，246例受试者（0.6%）报告了结核病，2459例（5.8%）死于肺癌。肺结核患者的肺癌死亡率显著高于非肺结核患者（25 vs 3.1/1000人-年）。这种关联在结核病诊断后的前5年尤为明显（风险比[HR]范围为6.7-13），但在结核病后5-9.9年（HR 3.4，95%CI 1.3-9.1）和10年以上（HR 3.0，95%CI 1.3-7.3）仍然很强。这些关联在男性和女性以及煤烟使用者（70.5%的受试者）中相似。人口统计学特征、肺病和烟草使用的调整对结果没有影响。在中国宣威，肺结核是肺癌的重要危险因素。在结核病诊断后持续数年的肺癌风险增加可能反映了结核病引起的慢性肺部炎症和疤痕的影响。
Tobacco and indoor air pollution from smoky coal are major causes of lung cancer in rural Xuanwei County, China. Tuberculosis has been suggested to increase lung cancer risk, but data from prior studies are limited. We conducted an analysis of data from a retrospective cohort study of 42,422 farmers in Xuanwei. In 1992, interviewers administered a standardized questionnaire that included lifetime medical history, including tuberculosis. Subjects were followed from 1976, with deaths from lung cancer ascertained through 1996. We used proportional hazards regression to assess the association between tuberculosis and subsequent lung cancer mortality. Tuberculosis was reported by 246 subjects (0.6%), and 2459 (5.8%) died from lung cancer during follow-up. Lung cancer mortality was substantially higher in subjects with tuberculosis than in those without (25 vs. 3.1 per 1000 person-years). The association was especially pronounced in the first five years after tuberculosis diagnosis (hazard ratios [HRs] ranging 6.7–13) but remained strong 5–9.9 years (HR 3.4, 95%CI 1.3–9.1) and 10+ years (HR 3.0, 95%CI 1.3–7.3) after tuberculosis. These associations were similar among men and women, and among smoky coal users (70.5% of subjects). Adjustment for demographic characteristics, lung disease, and tobacco use did not affect results. In Xuanwei, China, tuberculosis is an important risk factor for lung cancer. The increased lung cancer risk, persisting years after a tuberculosis diagnosis, could reflect the effects of chronic pulmonary inflammation and scarring arising from tuberculosis.
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中国东北部妇女中的肺癌。
影响因子：
8.8
作者：
Wu-Williams, A H;Dai, X D;Blot, W;Xu, Z Y;Sun, X W;Xiao, H P;Stone, B J;Yu, S F;Feng, Y P;Ershow, A G
通讯作者：
Ershow, A G
影响因子：
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作者：
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通讯作者：
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影响因子：
8.8
作者：
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通讯作者：
Gao YT
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
5
作者：
ALAVANJA, MCR;BROWNSON, RC;HOCK, E
通讯作者：
HOCK, E